How effective and safe is atropine on myopia control?
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Atropine has been found to be effective in controlling myopia progression and safe for use in children. Studies have shown that 0.01% atropine eye drops can significantly slow down myopia progression over a period of 5 years in a European population . Similarly, 0.05% atropine has been shown to effectively control axial length (AL) elongation and myopia progression in Chinese myopic children, with no significant progression of spherical equivalent refraction (SER) after atropine withdrawal . A meta-analysis of randomized controlled trials (RCTs) also supports the efficacy of atropine in slowing myopia progression, with the effect being dose-dependent. Low-dose atropine (0.01%) appears to be safer, with no significant adverse effects observed . Furthermore, an atropine-eluting contact lens has been developed, which has been shown to effectively control myopia progression in animal models . Overall, atropine has demonstrated effectiveness in controlling myopia progression and has been found to be safe for use in children.
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| Papers (5) | Insight |
|---|---|
10 May 2023 1 Citations | Atropine at doses of 0.005% and 0.01% effectively reduced myopia progression in children, while no effect was observed with a dose of 0.0025%. All doses of atropine were found to be safe and well tolerated. |
| The paper states that atropine-eluting contact lenses effectively delay the progress of form-deprivation myopia in guinea pig eyes, suggesting that atropine is effective in myopia control. The paper also mentions that the lenses reduced side effects in rabbit eyes, indicating safety. | |
| Atropine is effective in slowing the progression of myopia in children, with its efficacy being dose-dependent. Low-dose atropine (0.01% atropine) appears to be safer. The paper does not explicitly mention the safety of atropine, but it states that the rate of side effects was similar between the low-dose atropine group and the control group. | |
| The paper states that the use of 0.05% atropine for two consecutive years effectively controls the progression of myopia and is considered safe. | |
| Atropine 0.01% is effective in slowing myopia progression in a European population and has no side effects after 5 years of use. |
Related Questions
What are the latest guidelines on using atropine concentrations for myopia control?5 answersThe latest guidelines recommend using atropine 0.01% concentration for myopia control. Studies have shown that atropine 0.01% is more effective and safer than higher concentrations, with fewer adverse effects. This concentration has been found to be consistently effective in slowing myopia progression. Additionally, research indicates that 0.01% atropine eye drops are effective in non-Asian regions, achieving fewer side effects compared to higher concentrations. Guidelines suggest initiating treatment with 0.01% atropine, especially in pediatric populations, due to its benefits outweighing the side effects. Regular follow-ups with cycloplegic refraction every 3-6 months are recommended during treatment with atropine 0.01%.
What is the concentration of atropine used for tratement?4 answersThe concentration of atropine used for treatment varies depending on the study. According to the abstracts, different concentrations of atropine have been evaluated for myopia control, including 1%, 0.5%, 0.1%, and 0.01%, and 0.05%. The studies suggest that low concentrations of atropine, such as 0.01% and 0.05%, are effective in controlling myopia progression with minimal side effects. The ATOM 2 study found that 0.01% atropine is the optimal concentration with good efficacy and minimal side effects. The LAMP study also evaluated low concentrations of atropine, including 0.05%, 0.025%, and 0.01%, and found that 0.05% atropine was the optimal concentration for achieving the best efficacy and safety profile. Therefore, low concentrations of atropine, such as 0.01% and 0.05%, are commonly used for myopia treatment.
How to prevent myopia?5 answersTo prevent myopia, several methods can be employed. Increasing outdoor activity and reducing near work and screen time are recommended environmental modifications. Vitamin D supplementation, increasing indoor light intensity, and avoiding LED lights indoors are also suggested interventions. Spectacles such as progressive additional lenses and bifocals may slow myopia progression. Orthokeratology using RGP contact lenses overnight and certain designs of soft contact lenses have shown promising results. Low dose atropine eye drops and topical pirenzepine are available treatments to prevent myopia progression. Other potential therapies include auditory biofeedback, surgical interventions, and the use of antiglaucoma drops, although further research is needed. Additionally, a myopia prevention device with shaping components has been developed to gradually adjust the shape of the cornea and potentially correct myopia.
Can myopia be treated?5 answersMyopia can be treated through various methods. One approach is the use of dual-focus (DF) myopia-control contact lenses, which have been shown to focus light anterior to the central retina, reducing hyperopic defocus and increasing myopic defocus in the retinal image. Another method involves increasing nitric oxide levels or promoting the expression and activity of nNOS in ocular cells, which has been found to inhibit the development of myopia. Additionally, compositions containing a muscarinic receptor antagonist and a miotic agent have been shown to slow, inhibit, or regress the progression of myopia while minimizing pupil dilation and light sensitivity. These interventions aim to prevent or delay the onset of myopia and slow its progression, especially in individuals with higher myopic refractive errors who are at increased risk of vision-threatening complications.
Are there any systematic reviews on the efficacy of atropine drops in controlling myopia in children?5 answersThere are systematic reviews on the efficacy of atropine drops in controlling myopia in children. One review by Simonaviciute and Gelžinisdiscusses the history of attempts to reveal the mechanism of action of atropine and highlights the need for further study. Another review by Moriche-Carretero et al.evaluates the efficacy and safety of 0.01% atropine eye drops in controlling myopia progression over 5 years, finding that it is effective in slowing myopia progression in a European population with no side effects. Additionally, Mapangisana-Hlatywayocompares the effectiveness of 0.01% and 0.05% atropine eye drops in slowing down myopia progression, finding that both concentrations significantly slow down the progression of myopia with every other day use, with 0.01% atropine being better tolerated. Overall, these reviews provide evidence for the efficacy of atropine drops in controlling myopia in children.
What is the effect of fesoterodine on intraoccular pressure?5 answersFesoterodine does not have an effect on intraocular pressure according to the abstracts provided. The studies focused on the effects of fesoterodine on erectile dysfunction in diabetic rats, urethral function in women with stress urinary incontinence, urgency urinary incontinence in medically complex elderly subjects, physical function in older women with overactive bladder, and cardiac repolarization. None of the abstracts mentioned any impact of fesoterodine on intraocular pressure.