How extraction of tooth affect brain?
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Tooth extraction can impact the brain through various mechanisms. Studies have shown that decreased occlusal support following molar extraction can affect cognitive functions in mice, leading to decreased working memory and altered gene expression in brain regions related to neural activity and inflammation . Additionally, the presence of calcium silicate dental cements in extraction sockets can lead to changes in brain aluminum levels and oxidative stress parameters, potentially inducing oxidative stress and affecting antioxidant enzyme activity . Tooth loss has been associated with altered sensory, motor, cognitive, and emotional functions, leading to structural changes in brain regions involved in these functions, indicating a link between tooth loss and brain plasticity . Furthermore, experimental tooth loss in mice has been shown to reduce tight junction protein levels, induce astrogliosis, and impair learning functions, highlighting a potential association between tooth loss and cognitive dysfunction .
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| Papers (5) | Insight |
|---|---|
1 Citations | Experimental tooth loss in mice led to decreased claudin-5 levels, astrogliosis in the hippocampus, and impaired spatial learning, indicating a link between tooth loss and cognitive dysfunction. |
| Extraction of tooth 210 led to iatrogenic traumatic brain injury in a dog, causing neurological deficits. Careful dental procedures, especially for maxillary teeth, are crucial to prevent such complications. | |
29 Citations | Tooth extraction in female mice led to reduced gray matter volume in cortical regions for sensory, motor, cognitive, and emotional functions, along with increased volume in subcortical regions. |
| Tooth extraction induces hypothalamic and hippocampal astrogliosis, affecting cognitive functions and gene expression related to aging, neural activity, and neuroinflammation in aged mice. | |
22 Citations | Extraction of teeth with calcium silicate cements may transiently increase brain aluminium levels and oxidative stress, potentially impacting brain health. Further research is needed to understand long-term effects. |
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