How is Drosophila utilized in drug screening and validation processes?
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Drosophila is utilized in drug screening and validation processes by generating models that mimic genetic alterations in human cancers, such as pancreatic ductal adenocarcinoma (PDAC) . These models allow for comprehensive genetic screening of the entire kinome, leading to the identification of therapeutic targets, including kinases like MEK and AURKB . The efficacy of potential treatments can be tested by combining inhibitors of these targets, such as the MEK inhibitor trametinib and the AURKB inhibitor BI-831266, and evaluating their effects on the growth of human PDAC xenografts in mice . Drosophila models have also been used in high-throughput screening of FDA-approved drugs, leading to the identification of compounds that can reduce proliferation and rescue phenotypes in various cancer types . Additionally, Drosophila models have the potential for personalized therapies, where flies with the same mutations as a patient are used to screen multiple therapeutic agents and find the most appropriate combination of drugs . The use of Drosophila in drug screening and validation processes offers a whole-body approach that complements current methods and contributes to the current drug discovery pipeline .
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| Papers (5) | Insight |
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10 Nov 2022 | Drosophila is used in drug screening and validation processes by conducting chemical screens, gene-compound interaction studies, and testing effectiveness in genetic contexts to identify potential treatments and understand their mechanisms of action. |
| Drosophila is used in toxicological examinations to screen the toxicological profile of nanomaterials intended for use in higher eukaryotes, including humans. | |
3 Citations | Drosophila is used in drug screening by creating models of human cancers and screening FDA-approved drugs to identify compounds that reduce proliferation and rescue phenotypes. It is also used for personalized therapies by creating Drosophila 'avatars' with the same mutations as a patient to screen multiple therapeutic agents. |
| The paper describes the use of a Drosophila model to identify therapeutic targets for pancreatic ductal adenocarcinoma (PDAC) through comprehensive genetic screening of the kinome. | |
| The paper describes how a Drosophila model was generated to mimic the genetic alterations in pancreatic ductal adenocarcinoma (PDAC). This model was then used for comprehensive genetic screening to identify potential therapeutic targets, such as MEK and AURKB, for drug development. |
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