How is environmental enteric dysfunction detected normally?
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Environmental enteric dysfunction (EED) is typically detected using a combination of non-invasive biomarkers and intestinal biopsies. Non-invasive biomarkers, such as fecal biomarkers of gut inflammation (Alpha-1-antitrypsin, myeloperoxidase, and neopterin), can be measured using commercial enzyme-linked immunosorbent assay kits . These biomarkers can indicate the presence of abnormal gut leak and inflammation associated with EED. Intestinal biopsies, on the other hand, allow for a more detailed investigation of the underlying enteropathy in cellular and molecular detail, as well as measurement of important functional elements such as enzyme expression . Histology, electron microscopy, transcription and protein expression, physiological measures, and the microbiome can all be studied using intestinal biopsies to understand the pathophysiology of EED . While non-invasive biomarkers are valuable for large-scale studies, intestinal biopsies are still necessary for in-depth investigation of EED .
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4 Citations | Environmental enteric dysfunction (EED) is detected by measuring fecal biomarkers of intestinal epithelial damage, such as alpha-1anti-trypsin (AAT) and intestinal inflammation markers like Myeloperoxidase (MPO) and Neopetrin (NEO). |
7 Citations | Environmental enteric dysfunction (EED) is normally detected using non-invasive techniques, such as lactulose permeation tests, to assess abnormal gut permeability. |
| Environmental enteric dysfunction can be detected through endoscopic assessment, biomarkers, stable isotope assays, and -omics technologies. |
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