How is hexdecanoyk-CoA genearted using the fatty acid biosynthesis cycle?
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Hexadecanoyl-CoA, which is a crucial intermediate in fatty acid biosynthesis, is generated through a series of enzymatic reactions. Acetyl-CoA carboxylase catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, which serves as the activated donor of acetyl groups in fatty acid biosynthesis . The fatty acid biosynthesis cycle involves the condensation of acetyl-CoA and malonyl-CoA by acetyl-CoA carboxylase and fatty acid synthetase, leading to the formation of hexadecanoyl-ACP . This process is analogous to reverse β-oxidation and results in the production of hexadecanoyl-CoA, an essential precursor for the elongation of fatty acids beyond palmitate . The coordinated action of various enzymes, including acetyl-CoA carboxylase, fatty acid synthetase, and fatty acid elongase, is crucial for the generation of hexadecanoyl-CoA during fatty acid biosynthesis .
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| Papers (4) | Insight |
|---|---|
| Hexadecanoyl-CoA is generated in the fatty acid biosynthesis cycle through the action of enzymes like acetylCoA carboxylase and fatty acid synthase, which are upregulated in mitosis for lipid biosynthesis. | |
| Hexadecanoyl-CoA is generated in the fatty acid biosynthesis cycle by condensing acyl-ACP and acetyl-ACP using native or engineered thiolases in combination with type II fatty acid synthesis. | |
| Hexadecanoyl-CoA is generated in fatty acid biosynthesis by elongating palmitate in mitochondria or smooth endoplasmic reticulum, utilizing acetyl-CoA and malonyl-CoA as precursors for chain elongation. | |
| Hexadecanoyl-CoA is generated in the fatty acid biosynthesis cycle through the involvement of enzymes like acetyl-CoA carboxylase, fatty acid synthetase, desaturase, and elongase, as outlined in the paper. |
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