Search or ask a question

How many years living after living kidney transplant?

Survival analysis

Immunosuppression

Kidney transplantation

Transplantation

Best insight from top research papers

Living kidney transplant recipients have shown long-term graft survival, with some recipients achieving graft survival of ≥50 years . In one study, the overall graft survival rate was observed to be >80% after 13 years . Another study reported that living kidney donors who donated ≥50 years ago had a mean estimated glomerular filtration rate (eGFR) of 60.2 ± 13.4 mL/min/1.73 m2 for donors currently alive . Additionally, the median survival for living kidney donor transplants increased from 12.1 years in 1995-1999 to an estimated 19.2 years for transplants in 2014-2017 . These findings suggest that living kidney transplant recipients can experience long-term survival, with some recipients achieving graft survival for ≥50 years, and improvements in graft survival rates over time.

Answers from top 5 papers

PDF

Open Access

More filters

Papers (5)	Insight
Journal Article•DOI Long-term kidney transplant graft survival-Making progress when most needed. Emilio D. Poggio, Joshua J. Augustine, Susana Arrigain, Susana Arrigain, Daniel C. Brennan, Jesse D. Schold, Jesse D. Schold, Jesse D. Schold - Show less +7 more 08 Feb 2021-American Journal of Transplantation 45 Citations	The paper states that the median survival for living kidney donor transplants increased from 12.1 years in 1995-1999 to an estimated 19.2 years for transplants in 2014-2017.
Journal Article•DOI Four years' experience of live kidney donor follow-up: a single-centre study Maha Mohamed, Alison Callaway, Caroline Wroe - Show less +2 more 27 Sep 2016-Journal of Kidney Care	The provided paper does not mention the specific number of years that individuals live after a living kidney transplant.
Journal Article•DOI Kidney donor outcomes ≥ 50 years after donation. Daniel O. Keys, Scott A. Jackson, Danielle Berglund, Arthur J. Matas - Show less +3 more 08 Jul 2019-Clinical Transplantation 10 Citations	The provided paper does not mention the number of years a person can live after a living kidney transplant. The paper focuses on the long-term outcomes of living kidney donors who donated ≥50 years ago.
Journal Article•DOI Living donor kidney allograft survival ≥ 50 years Oscar K. Serrano, Arthur J. Matas - Show less +1 more 01 May 2017-Clinical Transplantation 2 Citations	The paper reports two cases of living donor kidney transplant recipients who have survived for more than 50 years with normal lifestyles and excellent quality of life.
Journal Article•DOI A Survival Analysis of Living Donor Kidney Transplant. S. Rodrigues, Rachele Escoli, C. Eusébio, Leonídeo Dias, Manuela Guedes de Almeida, La Salete Martins, S. Pedroso, António Castro Henriques, António Cabrita - Show less +8 more 01 Jun 2019 7 Citations	The paper states that the overall graft survival after living donor kidney transplant was greater than 80% after 13 years.

My columns

Related Questions

How has the survival for heart-transplantation changed over the years?4 answersSurvival for heart transplantation has improved over the years. In a single-center experience, the Kaplan-Meier survival curves at 5 and 10 years were 69% and 59% in the first decade, 62% and 52% in the second decade, and 66% and 60% in the third decade. Another study found that long-term survival was similar in recipients with donors of the same age ± 10 years and in recipients with donors >10 years older than them, but survival was lower when donors were >10 years younger than the recipients. A retrospective analysis showed that median survival for heart transplant recipients improved from the early era (12.6 years) to the mid era (14.9 years), and survival probability improved significantly from the mid era to the recent era. Additionally, a study investigating heart transplant recipients across three periods found that post-transplant 1-year survival was highest in the most recent period (93.0%).

What is the long-term survival rate of patients who receive a living kidney transplant?5 answersThe long-term survival rate of patients who receive a living kidney transplant is superior. Recipients who experience textbook outcomes (TO) after living donor (LD) kidney transplantation have better long-term survival rates compared to those who do not experience TO. The national average TO rate for LD transplant recipients is 54.1%. Additionally, the hazard ratio for death at 5 years for LD transplant recipients who did not experience TO was 1.92 (95% CI 1.68 to 2.18, p ≤ 0.0001). These findings suggest that patients who achieve TO after living kidney transplantation have a higher likelihood of long-term survival.

Can a 25 year old get kidney disease?6 answers

How long can you live with leukemia treatment?6 answers

How long do T and B cells live?5 answers

How old can neurons live in years?10 answers

See what other people are reading

How does inflammation contribute to the development and progression of stroke?

Inflammation plays a crucial role in the development and progression of stroke by impacting both the brain and peripheral organs. The acute inflammatory response post-stroke exacerbates brain injury, while systemic inflammation from peripheral organs like the spleen, lymph nodes, and gastrointestinal system also significantly contributes to secondary cell death in stroke. Moreover, infectious diseases and systemic inflammation increase the risk of stroke by interacting with hemostasis disturbances, endothelial damage, and cytotoxic lymphocytes activation. Atherothrombotic stroke, a common subtype, is driven by an inflammatory process in the vascular wall, leading to atherosclerosis and acute vascular events. Understanding these inflammatory mechanisms is crucial for developing effective therapeutic strategies to mitigate stroke pathology.How does the disruption of circadian rhythms affect pancreatic cancer?

Disruption of circadian rhythms has significant implications for pancreatic cancer progression. Studies have shown that circadian clock dysfunction, as evidenced by attenuated or dysregulated clock genes, accelerates tumor growth, worsens survival rates, and promotes chemoresistance in pancreatic cancer models. Furthermore, disruption of the circadian rhythm can lead to an exacerbated fibrotic phenotype in tumors, including pancreatic cancer, through mechanisms involving cancer-associated fibroblasts and the TGF-β signaling pathway. Epidemiological studies also suggest a link between circadian disruption, light at night exposure, and an increased risk of pancreatic cancer, highlighting the potential role of circadian disturbances in carcinogenesis. Additionally, circadian disruption can enhance tumor growth by promoting immunosuppression through the accumulation of myeloid-derived suppressor cells within the tumor microenvironment.How to make people younger by cell therapy ?

Cell therapy can potentially reverse aging by utilizing innovative techniques. Anti-Aging Regenerative Cosmetology (AARC) combines myoblasts and foreskin fibroblasts to enhance appearance and function, harnessing their regenerative properties for genetic cell therapy. Stem cells, derived from personalized sources, can regenerate organs like the heart, providing a youthful replacement for damaged tissues. Multipotent adult cells offer a novel approach to treat aging and diseases through transplantation to damaged areas. These advancements hold promise for sustaining good health, appearance, and life prolongation by improving cell genetics and organ functions. By leveraging the regenerative potential of various cell types, cell therapy emerges as a cutting-edge solution to combat aging and enhance overall well-being.How wharton jelly MSC affect nitric oxide pathway in hypertension?

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have been shown to impact the nitric oxide (NO) pathway in hypertension. Studies have demonstrated that WJ-MSC transplantation can enhance endothelial nitric oxide synthase (eNOS) expression, leading to increased NO production. Additionally, research has indicated that WJ-MSCs play a role in regulating NO levels through the upregulation of NO synthase in hypertensive conditions. Furthermore, the antihypertensive effects of royal jelly, which contains bioactive components similar to those found in WJ-MSCs, have been linked to increased NO production and vasorelaxation through the NO/cGMP pathway. These findings collectively suggest that WJ-MSCs and related substances may modulate the NO pathway to alleviate hypertension.Need for regulatory oversight to ensure safety??

Regulatory oversight plays a crucial role in ensuring safety across various industries. It involves a complex network of laws, regulations, and institutions that contribute to controlling high-hazard industrial activities, such as in the nuclear field. In the food industry, regulatory oversight is essential for ensuring the safety of functional foods like probiotics, which are gaining popularity for their health benefits. Enzymes, widely used in food processing, also require stringent safety assessments and regulatory frameworks to guarantee their safe application. Moreover, oversight in transplantation has shown the importance of quality oversight to ensure the safety and high quality of care in solid organ transplant centers. These examples underscore the critical need for regulatory oversight to maintain safety standards and protect consumers and the environment.Need for regulatory oversight to ensure safety?

Regulatory oversight is crucial to ensure safety in various industries. In the field of high-hazard industrial activities, a collaborative regulatory approach involving public and private entities enhances safety oversight. Similarly, in the food industry, regulatory considerations for probiotic-based foods are essential to protect consumers from safety risks and misleading claims. Moreover, in the nuclear sector, oversight of safety culture components is vital to reinforce defense mechanisms and improve safety culture within organizations. In transplantation, historical oversight has shown unintended consequences, emphasizing the need for policies that consider complexities and potential effects on patient care and organ utilization. Enzyme production, widely used in various sectors, requires safety assessments governed by global organizations like JECFA to ensure safe application in the food industry.How is UCP1 activated?

UCP1 activation involves various mechanisms. Adrenergic stimulation generates free fatty acids that activate UCP1, while Ca2+ futile cycling in beige fat can also induce thermogenesis. Fatty acids and other activators destabilize UCP1, shifting it to a less stable conformation conducive to proton leak. Additionally, ATP plays a role in inhibiting proton leak by controlling ionization states of specific residues. CRISPRa technology can enhance UCP1 expression in adipocytes, potentially aiding in thermogenesis. These findings highlight the complex interplay of factors involved in UCP1 activation, ranging from adrenergic stimulation to specific molecular interactions and gene expression modulation.How does dna profiling help find organ donor matches?

DNA profiling plays a crucial role in finding organ donor matches by providing valuable information for compatibility assessment. In forensic science, DNA profiling is utilized not only for criminal identification but also for determining personal characteristics of individuals through bacterial profiling. Additionally, DNA profiling aids in establishing the authenticity of reference samples for forensic analysis, ensuring accurate identification based on biological evidence. Moreover, the use of DNA profiling in forensic science extends to disaster victim identification and missing person investigations, showcasing its versatility in various fields. Therefore, by leveraging DNA profiling techniques, such as STR markers analysis and sequencing, medical professionals can accurately match organ donors with recipients based on genetic compatibility, ultimately improving the success rates of transplants.What dna profiling type finds the most successful organ donors?

DNA profiling in forensic casework plays a crucial role in identifying successful organ donors. In the field of organ transplantation, gene-expression profiling using RT-PCR methods has shown promise in improving patient and graft outcomes. The completion of the Human Genome Project has paved the way for personalized medicine in organ transplantation, utilizing next-generation sequencing (NGS) to identify specific biomarkers for successful donor transplantation. Graft-derived cell-free DNA (gdcfDNA) analysis, focusing on graft-specific DNA methylation patterns, has been successful in monitoring organ health post-transplantation, offering practical advantages over donor-recipient genotyping. Additionally, a novel approach using mRNA markers has been developed to differentiate between various organ tissues, providing a valuable tool for forensic characterisation of organ tissue in cases of violent crimes.What is the impact of alcohol consumption and liver cirrhosis on life expectancy globally?

The global impact of alcohol consumption on life expectancy, particularly through its role in liver cirrhosis, is profound and multifaceted. Alcohol consumption is a significant risk factor for morbidity and mortality, contributing to approximately 5.3% of all global deaths and a substantial burden of disease, including liver cirrhosis, which is a leading cause of liver transplantation in the western world. The burden of alcohol-associated liver disease (ALD) is considerable, accounting for 5.1% of all disease and injury worldwide, with alcohol use disorder (AUD) disproportionately affecting men and leading to significant years of life lost to disability across various countries. Globally, the mortality cases of cirrhosis have increased by 47.15%, with alcohol consumption being a major etiological factor alongside hepatitis C virus (HCV) and non-alcoholic steatohepatitis (NASH). This increase is particularly notable in regions with a middle-high sociodemographic index (SDI) and Eastern Europe, indicating a need for targeted strategies to limit alcohol consumption and promote healthier lifestyles. Despite these challenges, survival rates for patients with alcohol-associated liver disease who undergo liver transplantation have improved modestly over time, although life expectancy remains significantly reduced compared to the general population. The global prevalence and burden of disease for alcoholic cirrhosis (AC) and alcoholic liver cancer (ALC) have shown that Central Asia and East Europe bear the highest burden, with male gender identified as a significant risk factor. Alcohol consumption's impact on life expectancy is further exacerbated by its association with a wide range of adverse medical implications affecting nearly every organ system, underscoring the critical need for comprehensive interventions to reduce alcohol consumption and its related health impacts. In summary, alcohol consumption significantly impacts global life expectancy through its direct association with liver cirrhosis and other alcohol-related diseases. Efforts to mitigate this impact require a multifaceted approach, including public health interventions, targeted strategies in high-risk regions, and improved treatment and management options for those affected.How do uterus transplants affect a patient's self-esteem and body image?

Uterus transplants have shown to impact a patient's self-esteem and body image positively. Women undergoing uterus transplantation often describe themselves as feeling 'back to normal' post-surgery, regardless of successful childbirth. The procedure is perceived as a means to become a 'complete' woman, influencing self-perception, body image, and sexuality. Despite potential challenges like graft rejection or unsuccessful pregnancies leading to psychological strains, recipients generally report an overall positive experience with uterus transplantation, enhancing various facets of their lives. The psychological aspects of events post-transplantation, including health of the graft, rejections, complications, pregnancy outcomes, and hysterectomy, are crucial considerations in understanding the impact on self-esteem and body image.