How to affect antibiotic resistance ise of mouthwash?
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Exposure to chlorhexidine mouthwash can potentially lead to the development of antibiotic resistance in bacteria, including Neisseria gonorrhoeae. Studies have shown that sustained pressure from chlorhexidine can increase resistance not only to chlorhexidine itself but also to other antibiotics like azithromycin and ciprofloxacin . Additionally, certain bacteria in dental plaque have shown reduced susceptibility to chlorhexidine, potentially leading to multidrug resistance . While antimicrobial mouthwashes play a role in preventing antimicrobial-resistant Neisseria gonorrhoeae, their effectiveness varies, and the presence of saliva can impact their inhibitory activity . Furthermore, the misuse and overuse of antibiotics, including those found in mouthwashes, contribute significantly to the global issue of antibiotic resistance .
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| Papers (5) | Insight |
|---|---|
| Innovative drug delivery systems in mouthwashes can reduce antibiotic resistance by directly targeting infected tissues, enhancing antibiotic effectiveness, and minimizing systemic side effects. | |
| Mouthwash containing chlorhexidine may contribute to antibiotic resistance in dental plaque bacteria by promoting multidrug resistance, potentially reducing effectiveness against resistant species. | |
| Using Listerine Cool Mint mouthwash did not significantly reduce STI incidence or impact antibiotic resistance in high-risk populations taking HIV pre-exposure prophylaxis, as per the study findings. | |
3 Citations | Sub-inhibitory concentrations of chlorhexidine in mouthwash can induce resistance to chlorhexidine and decrease antibiotic susceptibility in Neisseria gonorrhoeae, potentially leading to cross-resistance to other antibiotics. |
| Antibacterial mouthwashes and antiseptics show varying inhibitory activity against Neisseria gonorrhoeae, suggesting potential impact on addressing antimicrobial resistance in the bacteria. |
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How do different types of resistance affect the effectiveness of antibiotics against microorganisms?5 answersDifferent types of resistance mechanisms impact the effectiveness of antibiotics against microorganisms. Antibiotic resistance can arise naturally through genetic mutations or horizontal gene transfer, leading to multi-resistant organisms that are challenging to treat. Bacteria develop resistance by limiting drug uptake, modifying drug targets, inactivating drugs, or actively pumping out antibiotics. This resistance not only affects hospital settings but also community environments, posing a significant public health concern. The misuse of antibiotics accelerates resistance development, necessitating judicious antibiotic use to combat this global issue. Understanding resistance patterns aids in selecting appropriate antibiotics for treating multidrug-resistant infections, emphasizing the importance of responsible antibiotic prescribing and infection control practices.
How does the use of antibiotics affect the development of antibiotic-resistant bacteria?5 answersThe use of antibiotics can lead to the development of antibiotic-resistant bacteria. Antibiotic resistance occurs when bacteria change in response to the usage of these drugs. This resistance can be transferred from animals to humans through direct contact, the food chain, and the environment. The extent of this relationship between antibiotic usage and resistance is not well characterized at an ecological level, but studies have shown that increases in antibiotic usage at the national level can increase antibiotic resistance nationally and internationally. Antibiotic usage in agriculture also contributes to the emergence of antibiotic-resistant genes (ARGs) in the intestinal microbiota of animals, which can be transferred to organisms through waste excreted in agricultural fields. Wastewater, which contains antibiotic residues, is another important reservoir for antimicrobial resistance, and the interactions between antibiotics in wastewater can affect the development of resistance in bacteria. Overall, the misuse and overuse of antibiotics in various settings contribute to the development of antibiotic-resistant bacteria and genes, posing a global threat.
What affect does cleaning have on resistant bacteria?4 answersCleaning has been shown to decrease environmental contamination of multidrug-resistant bacteria such as Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA). However, persistent contamination still poses a significant risk for transmission. In residential aged care facilities, low levels of resident colonization and environmental contamination with resistant gram-negative bacteria have been observed. Antibacterial cleaning and hygiene products used in households did not lead to a significant increase in antimicrobial drug resistance after one year. Regular cleaning of high-touch surfaces in healthcare facilities has been found to reduce microbial load and maintain low colony counts. Overall, cleaning plays an important role in reducing the presence of resistant bacteria and preventing healthcare-associated infections.
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