How to best decrease the release of acetylcholine?
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To effectively decrease the release of acetylcholine (ACh), several approaches can be considered based on the findings from the provided research contexts. Inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) has been shown to significantly reduce ACh release during wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep . Additionally, compounds like 4-aminopyridine (4AP) and LF14 have been found to lower the calcium requirements for evoked ACh release, potentially offering a strategy for reducing ACh release . Furthermore, inhibiting the mobilization of ACh from reserve depots to release sites or directly inhibiting the release process itself can also decrease stimulated ACh release . These findings collectively suggest that targeting NOS, altering calcium levels, or inhibiting specific processes involved in ACh release could be effective strategies to decrease ACh release.
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12 Citations | To decrease acetylcholine release, use carbamoylcholine, which inhibits release and can be partially reversed by atropine. High K+ levels can also block increased release. |
12 Citations | Inhibition of mobilization of acetylcholine can be achieved by using nondepolarizing muscle relaxants like d-tubocurarine, which decrease ACh release from reserve depots to release sites. |
13 Citations | To decrease acetylcholine release, consider increasing extracellular calcium levels or using compounds like 4-aminopyridine or LF14, which reduce calcium requirements for release, as shown in rat cortex slices. |
54 Citations | Inhibition of nitric oxide synthase in the medial pontine reticular formation effectively decreases acetylcholine release, as shown in the study. |
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