How to combine microfluidic chip with biosensor?
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Microfluidic chips can be combined with biosensors by integrating a microelectrode and a cathodic photoelectrochemical (PEC) biosensor on the chip . This integration allows for the ultrasensitive detection of specific biomarkers, such as non-small cell lung cancer cytokeratin fragments. The microfluidic chip utilizes a signal amplification strategy based on the p-n junction of AgI/Bi2Ga4O9 and a superoxide-dismutase-loaded honeycomb manganese oxide nanostructure (SOD@hMnO2) as the co-catalyst signal amplification label. This amplification strategy enhances the cathodic PEC behavior, resulting in excellent linearity and a low detection limit for the targeted detection objects . Additionally, microfluidic chips can be combined with surface-enhanced Raman scattering (SERS) substrates to create biosensor chips with various indicator selection functions . The biosensor chip consists of an upper module and a lower module, which includes a microfluidic device and a SERS substrate. This combination enables the diagnosis of various cancers by collecting light reflected after irradiating a laser to a test sample . Microfluidic-chip integrated optical biosensors have also been developed for simultaneous detection of multiple analytes. The microfluidic chip provides an ideal platform for the integration of high-throughput biosensors, allowing for the analysis of multiple analytes in a single device . Furthermore, microfluidics can be integrated with solid-state nanopores to create stand-alone devices for nucleic acid and protein characterization. The microfluidic device combines a bioassay reaction/purification chamber with a solid-state nanopore sensor, allowing for sample preparation, purification, and electrical readout detection in a single device .
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26 Citations | The paper describes the combination of a microfluidic chip with a biosensor by using micro-machining and heat bonding techniques to form the chip. |
01 Jan 2018 32 Citations | The paper discusses the integration of microfluidics in biosensor technology, offering new opportunities for future biosensing applications. It describes the fabrication and designing of microfluidics platform technology for biosensors. |
123 Citations | The paper provides a comprehensive review of the recent advances in combining microfluidic chips with optical biosensors for simultaneous detection of multiple analytes. |
23 Citations | The paper describes the design of a microfluidic chip integrated with a cathodic photoelectrochemical (PEC) biosensor for the ultrasensitive detection of cytokeratin fragments. It explains the mechanism for signal amplification using a p-n junction and a co-catalyst signal amplification label. However, it does not specifically mention how the microfluidic chip is combined with the biosensor. |
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