How to increase levothyroxine absorption? 

To enhance levothyroxine (LT4) absorption, several strategies can be implemented based on the data from the provided contexts. Firstly, conducting an LT4 absorption test with a standardized protocol involving fasting before the test, administering a specific dose of LT4, and monitoring blood samples hourly for at least 4 hours can help assess absorption efficiency . Additionally, in cases of suspected malabsorption, switching to a liquid LT4 formulation may improve absorption and aid in reaching target TSH levels . Moreover, optimizing the timing of LT4 ingestion, such as taking it before bedtime, can also positively impact absorption and thyroid hormone levels . Lastly, addressing underlying conditions like lactose intolerance, coeliac disease, or gastrointestinal disorders can further improve LT4 absorption and efficacy in managing hypothyroidism .

Marked Improvement of Levothyroxine Malabsorption by Simply Changing the Timing of Thyroxine Ingestion in an Adult Woman With Hypothyroidism After Radioiodine Therapy for Graves’ Disease

Changing the timing of levothyroxine ingestion, such as taking it at bedtime, can improve absorption and efficacy in patients with hypothyroidism resistant to treatment.

Adequate timing and constant supervision are the keys for successful implementation of levothyroxine or levothyroxine/paracetamol absorption test.

Adequate timing, constant supervision, and frequent sampling (e.g. every 30 minutes) are crucial for successful levothyroxine absorption. Paracetamol coadministration may be unnecessary in such cases.

The use of levothyroxine absorption tests in clinical practice.

To increase levothyroxine absorption, consider adjusting the dose, changing the formulation or administration route, or referring the patient to a gastroenterologist based on absorption test results.

The influence of lactose intolerance and other gastro-intestinal tract disorders on L-thyroxine absorption.

To increase levothyroxine absorption, take it on an empty stomach, consider lactose intolerance, and address gastrointestinal disorders like coeliac disease or H. pylori infection.

Cystic Fibrosis as a Cause of Malabsorption and Increased Requirement of Levothyroxine.

Switching to liquid levothyroxine formulation can enhance absorption in conditions like cystic fibrosis, aiding in reaching target TSH levels and managing hypothyroidism effectively.