What gene have impact for lactose intolerance?5 answersThe gene that significantly impacts lactose intolerance is the LCT gene, which encodes lactase synthesis. Lactose intolerance arises due to decreased lactase activity in adults, leading to the inability to digest lactose effectively. Genetic variations in the LCT gene, particularly a SNP (C>T) at position -13910, play a crucial role in lactase persistence in certain populations. Additionally, lactase non-persistence (LNP) is associated with specific genotypes upstream of the lactase gene, such as the CC genotype of −13910C > T. Understanding the genetic mechanisms behind lactase activity regulation is essential for guiding dietary interventions and addressing lactose intolerance in individuals.
Is ethanol inhibitor of lactose?4 answersEthanol does not directly inhibit lactose; however, it affects lactate metabolism. Research shows that oral ethanol administration in humans leads to hyperlacticacidemia due to decreased lactate disposal, not increased production. On the other hand, lactose esters, such as LMO, LMD, LML, and LMM, have microbial inhibitory properties, with LML being the most effective against Gram-positive bacteria. Additionally, the study on the effect of alcohol dehydrogenase inhibitors and substrates like ethanol on lactate dehydrogenase (LDH) activity found that ethanol increased LDH activity, potentially impacting lactate levels. Therefore, while ethanol does not directly inhibit lactose, it can influence lactate metabolism, which is distinct from the inhibitory properties of lactose esters on microbial growth.
What is the lactose content for goat, sheep and cow milks?4 answersThe lactose content for goat milk is approximately 4.39%. Sheep milk has a higher percentage of total solids compared to cow milk, but there is no specific mention of lactose content for sheep milk. The lactose content for cow milk is not explicitly mentioned in the abstracts provided.
Can lactose intolerance be cured?5 answersLactose intolerance cannot be cured, but it can be managed through various methods. One approach is to consume lactose-free dairy products, which have improved in quality and availability in recent years. Another method involves replacing the enzyme lactase through enzyme replacement therapy or consuming exogenous enzymes. Following a lactose-free diet and using prebiotics and probiotics are also common strategies for managing lactose intolerance. Additionally, there are methods for gradually increasing lactose intake to decrease symptoms of lactose intolerance over time. While lactose intolerance cannot be completely eliminated, these approaches can help individuals with lactose intolerance manage their symptoms and improve their quality of life.
What is the effect of lactose free ice cream on lactose intolerance?5 answersLactose-free ice cream is a promising direction of research for people who cannot tolerate lactose. The development of lactose-free ice cream involves obtaining a protein-lipid concentrate with low lactose content and high protein content. This concentrate is fermented with synbiotic sourdough to create a lactose-free synbiotic yogurt ice cream. The lactose content in lactose-free ice cream is significantly reduced, with some samples containing as little as 0.011% lactose. Lactose-free ice cream also has high probiotic activity, containing lacto- and bifidobacteria. Additionally, low-lactose ice cream formulations with antioxidant and pre-probiotic properties have been developed using secondary milk and plant material. These formulations have similar organoleptic parameters to regular ice cream and have a reduced lactose content. Enzymatic hydrolysis can also be used to decrease the lactose content in ice cream, without affecting the other physicochemical and microbiological parameters.
What is the rate of lactose hydrolysis of Bacillus licheniformis lactase?4 answersThe rate of lactose hydrolysis of Bacillus licheniformis lactase is influenced by various factors. The optimum temperature and pH for lactose hydrolysis by the enzyme were found to be 50°C and 6.5, respectively. The enzyme is stable over a wide range of pH (5-9) and temperatures (4-42°C). The enzyme is strongly inhibited by the hydrolysis products, glucose and galactose. The transgalactosylation potential of the enzyme for the production of galacto-oligosaccharides (GOS) from lactose was found to be low. The rate of lactose hydrolysis can be described using an empirical model that takes into account the enzyme activity and reaction time. The lactase from Bacillus licheniformis exhibited properties that allowed for lactose hydrolysis over a broader range of conditions compared to other lactases.