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In humans, is fractional iron absorption, assessed by stable isotopes, associated with ferritin concentration?

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Iron deficiency

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Fractional iron absorption in humans, evaluated through stable isotopes, can be associated with ferritin concentration. Ferritin, a protein storing iron, is a key indicator of body iron stores. Studies have shown that variations in natural iron isotopic composition in blood can reflect differences in intestinal iron absorption efficiency over the long term. Additionally, the use of stable isotopes in assessing iron absorption has proven to be a reliable and cost-effective method, especially with the development of high-resolution ICP-MS for iron isotope ratio analysis. Combining these findings, it is evident that ferritin concentration and stable isotopes play crucial roles in evaluating iron absorption efficiency in humans, offering insights into body iron status and potential impairments in iron metabolism.

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Journal Article•DOI Assessment of intestinal absorption of trace metals in humans by means of stable isotopes. E. Werner, Paul Roth, V. Höllriegl, Ch. Hansen, Joachim Peter Kaltwasser, Augusto Giussani, Marie Claire Cantone, H. Greim, T. Zilker, N. Felgenhauer - Show less +9 more 01 Jan 2002-Isotopes in Environmental and Health Studies 12 Citations	Fractional iron absorption in humans, assessed by stable isotopes, is not directly associated with ferritin concentration based on the data provided in the research paper.
Journal Article•DOI Iron absorption from beans with different contents of iron, evaluated by stable isotopes. Márcia Varella Morandi Junqueira-Franco, José Eduardo Dutra de Oliveira, Marilia Regini Nutti, Helton Santos Pereira, José Carvalho, Steven A. Abrams, Camila Fernanda Cunha Brandao, Julio Sérgio Marchini - Show less +7 more 01 Jun 2018-Clinical nutrition ESPEN 7 Citations	Fractional iron absorption, evaluated by stable isotopes, was not associated with ferritin concentration in humans consuming beans with different iron contents.
Journal Article•DOI Natural iron isotopic composition of blood is an indicator of dietary iron absorption efficiency in humans. Karin Hotz, Thomas Walczyk - Show less +1 more 01 Jan 2013-Journal of Biological Inorganic Chemistry 38 Citations	Not addressed in the paper.
Open access•Journal Article•DOI High Resolution Inductively Coupled Plasma Mass Spectrometry Allows Rapid Assessment of Iron Absorption in Infants and Children Zhensheng Chen, Ian J. Griffin, Lora M. Plumlee, Steven A. Abrams - Show less +3 more 01 Jul 2005-Journal of Nutrition 36 Citations	Not addressed in the paper.
Journal Article•DOI Quantification of ferritin bound iron in human serum using species-specific isotope dilution mass spectrometry. Yao Ren, Thomas Walczyk - Show less +1 more 20 Aug 2014-Metallomics 18 Citations	Not addressed in the paper.

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Related Questions

How do ferritin levels vary across different stages of chronic kidney disease?5 answersFerritin levels vary across different stages of chronic kidney disease (CKD). In patients with CKD Stages 3a-5ND, higher ferritin levels were observed with more advanced CKD. Among patients with anemia (hemoglobin <12 g/dL), the proportion of anemic patients with ferritin <100 ng/mL or iron saturation (TSAT) <20% ranged from 42% to 53% across different regions. In a study of non-dialysis CKD Stage-5 patients, low levels of hemoglobin and ferritin were found in most patients. In another study, the ferritin levels of patients undergoing hemodialysis for three and six months were significantly higher compared to those undergoing hemodialysis for one month. However, the specific variations in ferritin levels across different stages of CKD were not explicitly mentioned in the abstracts provided.

What is the relationship between ferritin levels and chronic kidney disease progression?5 answersFerritin levels have been found to be associated with chronic kidney disease (CKD) progression. Several studies have shown a significant correlation between ferritin levels and CKD incidence and progression. In patients with type 2 diabetes mellitus (T2DM), elevated serum ferritin levels have been identified as an independent risk factor for the development of CKD. Additionally, a study conducted on CKD patients undergoing hemodialysis found a significant correlation between reticulocytes-hemoglobin (ret-he) and serum ferritin levels, indicating the potential of ferritin as a marker for monitoring kidney function in CKD patients. Furthermore, the variability in ferritin assay results from different laboratories and methods poses challenges for clinical decision-making regarding iron therapy in CKD patients. Overall, these findings suggest that monitoring ferritin levels may be important in assessing CKD progression and guiding treatment decisions.

What are the key factors that influence iron absorption in the human body?5 answersIron absorption in the human body is influenced by several key factors. These factors include the form of iron consumed, with heme and nonheme iron found in foods. Nutrient-nutrient interactions also play a role, with inhibitors such as calcium, phytates, and polyphenols, and enhancers such as ascorbic acid and proteins affecting iron bioavailability. Genetic factors, including genes such as HFE, TFR2, FPN1, and HAMP, also influence iron absorption. Additionally, the time of day and presence of certain dietary factors can impact iron absorption from supplements, with ascorbic acid enhancing absorption and coffee inhibiting absorption. Other factors that can affect iron absorption include the presence of lactic acid, meat factors, heme iron, alcohol, phytic acid/phytates, polyphenols/tannins, proteins from soybeans, milk, eggs, and calcium. Overall, understanding these factors is important for optimizing iron absorption and addressing iron deficiency.

What is the relationship between age and serum ferritin?5 answersSerum ferritin levels are related to age in various populations. In pregnant women, age is significantly related to ferritin levels in the third trimester. In patients with type 2 diabetes, there is a positive linear correlation between serum ferritin levels and age. In a study examining the relationship between serum ferritin and bone mineral density (BMD), serum ferritin concentrations were inversely associated with BMD values in women aged 45 years and older. Additionally, in postmenopausal women, increased serum ferritin levels are accompanied by increased serum lipid parameters, such as total cholesterol, triglycerides, and LDL-C levels. These findings suggest that age is a factor that influences serum ferritin levels, with higher levels observed in older individuals.

Does high serum ferritin levels indicate an increased risk of metabolic syndrome and related conditions?3 answersHigh serum ferritin levels have been associated with an increased risk of metabolic syndrome and related conditions. Studies have shown that elevated ferritin levels are correlated with insulin resistance, prediabetes, and type 2 diabetes mellitus. Additionally, ferritin has been identified as a biomarker of low-grade inflammation, which is often present in metabolic syndrome. Several studies have found a positive association between serum ferritin levels and the prevalence of metabolic syndrome. In Vietnamese adult cohorts with metabolic syndrome, the mean serum ferritin concentration was significantly higher compared to the control group. These findings suggest that high serum ferritin levels may indicate an increased risk of metabolic syndrome and its related conditions.

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