What topical steroids are safe in pregnancy?5 answersLow- to midpotency topical corticosteroids are generally considered safe during pregnancy, while the extensive use of high-potency corticosteroids may be associated with low birth weight. A large cohort study found no association between topical corticosteroid use in pregnancy and an increased risk of small for gestational age (SGA) or low birth weight, even with the use of potent to very potent agents. However, maternal use of potent/very potent topical corticosteroids, especially in large amounts, is linked to an increased risk of low birth weight, emphasizing the preference for mild/moderate topical corticosteroids during pregnancy. Therefore, when considering topical steroids during pregnancy, it is advisable to opt for low- to midpotency options to minimize potential risks to the fetus.
What are the precautions for the use of ectoin in cosmetics ?4 answersPrecautions for using ectoin in cosmetics include determining the optimal optical purity for enhanced safety and efficacy, as higher purity levels correlate with lower cytotoxicity and increased anti-inflammatory and anti-allergic activity. Ectoine's addition to anionic surfactants can reduce irritant potential, decrease sebum solubilization, and lower cytotoxicity, enhancing the safety of cleansing products. Ectoine's protective properties shield human skin cells from UV-A radiation damage, making it a valuable ingredient in cosmetics and pharmaceuticals, with potential applications in cancer radiation therapy. Ectoin's application in maintaining the skin's microecological balance can aid in treating dermatitis, sunburn, and other skin conditions, while also promoting the growth of beneficial bacteria. Overall, understanding ectoin's benefits and optimal concentrations is crucial for safe and effective use in cosmetic formulations.
Is it safe to use topical steroids in pregnancy?5 answersTopical corticosteroids are commonly used during pregnancy to treat various skin conditions. The available evidence suggests that maternal use of topical corticosteroids, regardless of potency, is generally safe and not associated with adverse pregnancy outcomes such as mode of delivery, birth defects, preterm delivery, fetal death, and low Apgar score. However, there is a possible association between the use of potent to very potent topical corticosteroids and low birth weight, especially with large cumulative dosages throughout pregnancy. It is important to note that the systemic absorption of topical corticosteroids during pregnancy is minimal, making them safer than oral or parenteral agents. Nevertheless, caution should still be exercised, as the available data on the safety of topical corticosteroids in pregnancy is limited. Further research is needed to fully understand the potential risks and benefits of using topical corticosteroids during pregnancy.
What is the impact of oxytocin ingestion on pregnant women?5 answersOxytocin ingestion in pregnant women has varying effects depending on the specific context. In pregnant women treated with atosiban (an oxytocin antagonist) to arrest preterm labor, no adverse effects on the cardiovascular system or heart rate modulation were observed. Continuous infusion of low-dose oxytocin during induction of labor did not significantly affect selected cerebral hemodynamic parameters in the first 2 hours after initiation. Oxytocin usage during delivery may increase the duration of labor, but increasing the dose of oxytocin does not increase the risk of adverse pregnancy outcomes in women with poor uterine contraction. However, in women with severe preeclampsia, oxytocin administration resulted in an increase in heart rate, a decrease in systemic vascular resistance, and a decrease in blood pressure, with some patients experiencing a decrease in cardiac output. The presence of certain genetic variants of the oxytocin and oxytocin receptor genes, combined with a history of emotional abuse during childhood or adolescence, increased the risk of prenatal depressive symptoms in pregnant women.
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