How does nigella sativa inhibit the SARS-CoV-2 spike protein?5 answersNigella sativa inhibits the SARS-CoV-2 spike protein through its bioactive components like thymoquinone and nigellidine. These compounds exhibit strong binding activity with key residues of the spike protein, such as Asp467, Thr108, and Ile468, interfering with the protein's function. Additionally, molecular docking studies show that nigellidine forms bonds with amino acid CYS240 in the binding pocket of COVID-19 Nsp2, indicating its inhibitory potential against the virus. The interactions between Nigella sativa compounds and the spike protein are crucial for developing potential inhibitors against SARS-CoV-2, highlighting the plant's promising role in combating COVID-19. Further experimental validation is necessary to confirm the efficacy of these compounds as inhibitors of the SARS-CoV-2 spike protein.
Does Nigella sativa affect salivary function?5 answersNigella sativa has been shown to have a protective effect on salivary function. In a study by Saleh Mouket et al., it was found that Nigella sativa oil (NSO) reduced oxidative/nitrosative stress markers and had antioxidant effects, which augmented the antioxidant capacity in the salivary tissue of rats. Another study by Wael Amin Nasr El-Din et al. demonstrated that NSO ameliorated hypothyroidism-induced parotid gland pathological alterations, indicating its positive effect on salivary gland integrity. Additionally, Enas Hegazy et al. found that Nigella sativa seeds protected against hypercholesterolemia-induced histological changes in the submandibular salivary glands of rats. Furthermore, Hazha Abdullah Mohammed Ameen et al. showed that NS oil mouthwash had anti-inflammatory activity and reduced the severity of radiation-induced oral mucositis in head and neck cancer patients. Overall, these studies suggest that Nigella sativa has a beneficial effect on salivary function.
How does Nigella sativa affect hyprtnsionn?4 answersNigella sativa supplementation has been shown to effectively reduce blood pressure in adults. It can significantly decrease both systolic and diastolic blood pressure. Nigella sativa seeds have been found to have anti-hypertensive effects and can significantly reduce blood pressure in patients with hypertension. Nigella sativa has also been associated with antihypercholesterolemic and antihyperglycemic properties, which contribute to its ability to lower blood pressure. Nigella sativa seeds oil, when used as a complementary treatment, has been found to have additional antihypertensive effects and can improve glucose control and lipid metabolism in hypertensive patients. Nigella sativa oil has been shown to significantly reduce blood pressure in hypertensive adults, making it a potential alternative therapy for hypertension.
What are the potential benefits of Nigella sativa for autoimmune diseases?5 answersNigella sativa, also known as black cumin seed, has potential benefits for autoimmune diseases. Studies have shown that black cumin seed oil can combat superbugs like Methicillin-resistant Staphylococcus aureus (MRSA) and Helicobacter pylori. It has also been found to have anti-asthmatic effects and can be more effective than conventional treatments. Additionally, black cumin seed oil has been shown to reduce inflammation and oxidative stress, which are important factors in the development of chronic diseases such as cardiovascular disease, Type 2 diabetes, and rheumatoid arthritis. The active compounds in black cumin seed oil, such as thymoquinone, possess properties that can be utilized in the treatment of neurodegenerative diseases. Furthermore, Nigella sativa has been found to have immunomodulatory effects, which can be beneficial in managing autoimmune diseases. Overall, Nigella sativa shows promise as a natural remedy for autoimmune diseases due to its various therapeutic properties.
What are the benefits of nigella sativa oil?5 answersNigella sativa oil has a wide range of benefits. It has anti-inflammatory, antibacterial, antifungal, antiparasitic, antiviral, cytotoxic, anticancer, neuroprotective, gastroprotective, cardioprotective, and hepatoprotective properties. It also has positive effects on the immunological, respiratory, and reproductive systems, as well as on diabetes mellitus, fertility, breast cancer, dyspepsia, and osmotic balance. Nigella sativa oil has been shown to be effective in the prevention of allergic rhinitis symptoms, with anti-inflammatory and anti-allergic effects comparable to a topical steroid. It has been used traditionally to remedy ailments such as headaches, fever, gastric complaints, and rheumatism. The oil has been found to have antioxidant, antitumor, and antibacterial activities, and may improve glucose homeostasis and lipid profile. Further research is needed to explore the cellular and molecular mechanisms of action of Nigella sativa oil and its components.
What are the best homeopathic medicines for allergic rhinitis?5 answersThe best homeopathic medicines for allergic rhinitis are arsenic album and sulphur.