Search or ask a question

Is NMN goog for longevity?

Degeneration (medical)

Best insight from top research papers

NMN (nicotinamide mononucleotide) shows promise for longevity . Research indicates that NMN, as an NAD precursor, plays a crucial role in maintaining NAD levels, which decline with age and are linked to age-related diseases. NMN supplementation is associated with activating SARM1, an enzyme involved in axon degeneration, raising questions about its potential harm despite its anti-aging benefits. Studies highlight the importance of NAD in aging interventions, with NAD precursors like NMN and NR showing potential in promoting longevity and addressing age-related complications. Additionally, experiments suggest that NMN may help prevent aging by increasing AMPK and NAD+ levels, essential factors for longevity. Therefore, while NMN holds promise for longevity, further research is needed to fully understand its effects and ensure its safety for prolonged use.

Answers from top 5 papers

PDF

Open Access

More filters

Papers (5)	Insight
Open access•Journal Article•DOI The first human clinical study for NMN has started in Japan Kazuo Tsubota 27 Oct 2016 37 Citations	Nicotinamide mononucleotide (NMN) is promising for longevity by augmenting NAD levels, benefiting glucose metabolism, cardiovascular functions, and potentially promoting longevity, as indicated in the research.
Open access•Journal Article•DOI NMN Nicotinamide Mononucleotide Activates Intracellular Energy and Approaches the Prevention and Improvement of Aging Satoshi Kawakami, Yoshitaka Fukuzawa, Hiroyuki Ichikawa, Tsutomu Sato, Takaharu Ide, Yusuke Maeda, Takahiko Yamamoto - Show less +6 more 01 May 2022-Journal of biomedical research & environmental sciences	NMN activates AMPK and NAD+, potentially aiding in preventing aging. It acts on sirtuin genes, suggesting it may be beneficial for longevity by promoting healthy aging.
Open access•Journal Article•DOI NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies Andrea Loreto, Christina Antoniou, Elisa Merlini, Jonathan Gilley, Michael P. Coleman - Show less +4 more 01 Jan 2023-Neuroscience research 1 Citations	NMN, a precursor to NAD, shows potential for anti-ageing therapies by boosting NAD levels. However, excessive NMN accumulation can lead to axon degeneration, raising concerns about its long-term use.
Open access•Journal Article•DOI Safety Evaluation for Restorin® NMN, a NAD+ Precursor John Turner, Albert Licollari, Emil Mihalcea, Aimin Tan - Show less +3 more 11 Nov 2021-Frontiers in Pharmacology 3 Citations	Sustaining NAD+ levels with Restorin® NMN, a high purity NMN precursor, shows potential benefits for healthspan and longevity based on safety evaluations in Sprague-Dawley rats.
Open access•Journal Article•DOI Longevity regulation by NMD-mediated mRNA quality control. Heehwa G. Son, Seung-Jae Lee - Show less +1 more 01 Apr 2017-Journal of Biochemistry and Molecular Biology 10 Citations	Not addressed in the paper.

My columns

Related Questions

How does supplementation with NMN affect cellular aging and longevity in humans?5 answersSupplementation with nicotinamide mononucleotide (NMN) has shown promising effects on cellular aging and longevity in humans. Research indicates that NMN supplementation can elevate NAD+ levels, which decline with age, potentially mitigating age-related functional decay. Studies have demonstrated that NMN administration can prevent the reduction of NAD+ levels, alleviate aging-related diseases, and improve physiological functions in aging models. Furthermore, NMN has been linked to reshaping the gut microbiota, reducing bacterial diversity, and potentially extending telomere length, a molecular marker of aging. These findings suggest that NMN supplementation may be a viable strategy to retard aging by influencing NAD+ metabolism, microbiota composition, and cellular aging processes, highlighting its potential as an anti-aging therapy in humans.

What does the longevity science deal with?5 answersLongevity science deals with understanding the mechanisms of aging and finding ways to extend the period of healthy lifespan. It focuses on identifying genetic and environmental factors that contribute to aging and developing interventions to slow down the aging process. Research in this field has identified several hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, and cellular senescence. Comparative studies across different species have also provided insights into the molecular signatures associated with exceptional longevity and variation in lifespan. These studies have identified potential strategies for lifespan regulation, cancer resistance, and pathways associated with longevity. The goal of longevity science is to improve human health during aging and increase the period of life spent free from chronic diseases and disability.

What does the longevity science deal with ?5 answersLongevity science deals with understanding the mechanisms of aging and finding ways to extend the period of healthy life free from chronic diseases and disabilities. It focuses on identifying genetic pathways and biochemical processes that control the rate of aging. The goal is to improve human health during aging with minimal side-effects by targeting the common denominators of aging, such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, and cellular senescence. Longevity science also explores the factors affecting health, aging, and longevity, and estimates the potential reserves of longevity and possible ways to achieve them. By understanding the basic mechanisms of aging and identifying conserved longevity factors, longevity science aims to develop interventions to slow aging in humans. It is a field of public health and preventive medicine that focuses on promoting health and extending the healthspan throughout the lifespan.

How to increase NAD and longevity?5 answersTo increase NAD and longevity, several strategies can be implemented. One approach is to use intravenous NAD+ therapy, which has been shown to increase blood NAD+ metabolome in elderly humans and slow down age-related decline in NAD+. Another method is to upregulate NAD metabolism through dietary supplementation with NAD precursors, which has been found to prevent the decline of NAD and exhibit beneficial effects against aging and aging-associated diseases. Additionally, enhancing autophagy, a cellular degradation pathway, and maintaining NAD levels have been shown to extend health/lifespan and normalize metabolic activity in cells. Furthermore, reducing activity of nutrient sensing pathways such as glucose-sensing PKA, nitrogen-sensing TOR, and S6 kinase homolog Sch9, as well as maintaining adequate NAD+ pools, have been linked to increased lifespan. Overall, these approaches provide potential therapeutic targets for promoting longevity and combating age-related diseases by regulating NAD metabolism.

Can NMN reduce aging?5 answersNMN supplementation has shown potential in reducing aging. Studies have indicated that NMN administration can lead to changes in the gut microbiota and metabolomes, which are associated with aging. Additionally, NMN has been found to increase AMPK and NAD+ levels, suggesting its potential in preventing aging. Furthermore, NMN has been shown to elevate NAD+ levels in the body, which can help alleviate age-related complications. NMN supplementation has also been found to increase the plasma concentrations of NMN and NAD+. These findings suggest that NMN supplementation in the pre-aging stage may be an effective strategy to retard aging. However, further studies are needed to unravel the underlying molecular mechanisms and validate the effects of NMN on aging through comprehensive clinical trials.

Could the timing of NMN intake accelerate aging?3 answersThe timing of NMN intake does not appear to accelerate aging. In fact, several studies suggest that NMN supplementation may have anti-aging effects. One study found that NMN administration in pre-aging mice and humans resulted in significant elongation of telomere length, a molecular gauge for aging. Another study conducted toxicity studies on Restorin® NMN and concluded that it is safe for oral administration, with no adverse effects observed at the recommended doses. Additionally, NMN has been shown to increase AMPK and NAD+ levels, indicating its potential to prevent aging. Furthermore, daily NMN ingestion has been found to elevate plasma levels of NMN and NAD+, suggesting its potential health benefits in alleviating aging and related diseases. Overall, the evidence suggests that NMN intake does not accelerate aging and may actually have anti-aging effects.

See what other people are reading

How does fatigue relate to mood state in children?

Fatigue in children has been found to be closely linked to mood states such as depression. Studies have shown that fatigue can mediate the relationship between depression and poor outcomes in children, indicating a significant association between the two factors. Furthermore, research on children with cancer demonstrated a notable relationship between depression and fatigue, with children exhibiting depressive symptoms experiencing higher levels of fatigue. Additionally, in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), depression was prevalent and associated with markers of disease severity, emphasizing the importance of screening and treating depression in this population. Overall, these findings underscore the intricate interplay between fatigue and mood states in children, highlighting the need for comprehensive assessments and interventions to address both aspects effectively.Explain the roles of black community programmes within aparthiedbstate?

Black community programs within apartheid states played crucial roles in addressing systemic racism, disparities in care, and lack of resources affecting black individuals. These programs aimed to provide culturally tailored services to meet the specific needs of black communities, particularly in healthcare settings where access to postacute services was limited. Additionally, in the education sector, community programs focused on developing parents' skills related to child development to prevent school failure, recognizing the critical influence parents have on their children's educational development. Furthermore, institutions of higher education founded for black individuals were seen as key players in community development, leveraging their singleness of purpose, homogeneity of clientele, and institutional flexibility to facilitate programs that address broader community needs.Whats a percent increase from 959,000 to 2,705,000

The percentage increase from 959,000 to 2,705,000 can be calculated as follows: Percentage Increase = ((New Value - Old Value) / Old Value) x 100 Substituting the given values: Percentage Increase = ((2,705,000 - 959,000) / 959,000) x 100 = 181.42% This significant percentage increase highlights a substantial growth from the initial value to the final value of 2,705,000. This growth mirrors the concerning trends observed in various areas such as alcohol use disorders, maternal mortality rates, and corporate payouts. These trends underscore the importance of addressing underlying issues and implementing effective strategies to mitigate the negative impacts associated with such increases.What is the disadvantages from the related literatures?

The disadvantages from the related literatures include the isolation between theoretical and policy literatures in the field of financial inclusion, hindering a comprehensive understanding and development of the concept. Additionally, in the medical field, the limitations of the Medical Literature Analysis and Retrieval System Online (MEDLINE) database are highlighted, as it may miss many relevant articles, especially in complex topics, leading to potential gaps in evidence-based practices. Moreover, challenges in the practice of medicine are noted, where time constraints and stringent algorithms can result in serious mistakes, impacting clinical outcomes negatively. These drawbacks emphasize the importance of bridging gaps between different types of literature and improving search methodologies to enhance knowledge dissemination and application.Falls-related injuries in the cervical spine FINITE ELEMENT ?

Fall-related injuries in the cervical spine are a significant concern, especially among older adults. Studies have shown a notable increase in the number and incidence of fall-induced severe cervical spine injuries over the years. Finite Element (FE) modeling has been utilized to develop and validate methodologies for simulating impact loading on vertebral bodies, aiding in understanding the biomechanics of cervical spine injuries. Research has highlighted the prevalence of cervical spine injuries in adults aged 65 and above after low-level falls, emphasizing the need for further investigation into the association between clinical exam findings and cervical spine injuries. Additionally, the incidence of fatal cervical spine injuries has been found to be on the rise, with specific risk factors such as age, mechanism of injury, and comorbidities like traumatic brain injury playing crucial roles in the occurrence of these injuries.How does clinical hipnosis as an independent therapy compare to clinical hipnosis as complementary therapy addressing NSSI: scooping review?

Clinical hypnosis as an independent therapy shows effectiveness in addressing Non-Suicidal Self-Injury (NSSI) based on evidence of its efficacy in treating various medical and psychological conditions. However, when used as a complementary therapy, clinical hypnosis enhances the effectiveness of conventional interventions, making it a recommended technique to improve a wide range of medical and psychological issues, ultimately enhancing patients' quality of life. Additionally, research indicates that clinical hypnosis has potential benefits for reducing procedural pain and distress in children, showing superiority to control conditions and nonpharmacological interventions in 76% of studies. Therefore, while clinical hypnosis can be effective as an independent therapy for NSSI, its use as a complementary therapy may offer additional advantages in enhancing treatment outcomes and improving overall well-being.Issues and challenges faced by aquaculture regionally as well as globally

Aquaculture faces various challenges globally and regionally. Globally, the sector grapples with technical, economic, and regulatory hurdles, such as developing efficient grow-out systems and feeds, integrating into global supply chains, and ensuring streamlined permitting and environmental oversight. Regionally, constraints on suitable aquaculture areas, environmental considerations, and social implications pose significant challenges for sustainable development and expansion of the industry. Disease outbreaks also present a major risk, with global economic impacts estimated at $6 billion annually, emphasizing the need for effective disease management strategies and tools. Additionally, the sector must navigate complexities related to water quality, habitat preservation, and social interactions to ensure responsible and sustainable aquaculture practices.What are some specific considerations for obese people starting exercise programmes?

Obese individuals initiating exercise programs should focus on gradual progression, injury prevention, and enjoyment of the activity. Preemptive strengthening exercises targeting foot, ankle, hip, quadriceps, and trunk muscles can enhance joint support before running. Starting with non-impact exercises like walking on flat surfaces or inclines can build endurance and calorie expenditure. Incorporating intermittent walk-jog programs and ensuring that musculoskeletal pain does not persist or increase post-exercise are crucial considerations. Additionally, a comprehensive evaluation of medical history and fitness level is essential before commencing any exercise regimen, which ideally should include a mix of cardiorespiratory, resistance, and flexibility exercises. Regular physical activity, rather than just focusing on weight loss, is emphasized for long-term health benefits.How does the temperature of the saline solution affect the oral microbiome in mechanically ventilated patients?

The temperature of the saline solution used in oral care for mechanically ventilated patients can impact the oral microbiome. Studies have shown that oral microorganisms can increase respiratory pathogen (RP) colonization in biofilms, emphasizing the importance of managing oral care effectively. Additionally, changes in the oral microbiome during mechanical ventilation (MV) have been linked to the presence of potential respiratory pathogens like Staphylococcus aureus and Pseudomonas aeruginosa in dental plaque. Proper oral care interventions, such as using different temperatures of saline solutions, may help prevent or reduce respiratory pathogen colonization in the oral cavity, potentially lowering the risk of ventilator-associated pneumonia (VAP) in critically ill patients.How does the use of cold saline versus room temperature saline affect the oral health of mechanically ventilated patients?

The comparison between cold saline and room temperature saline on the oral health of mechanically ventilated patients reveals significant findings. Cold saline oral swabs were found to be more effective in decreasing thirst intensity and improving oral condition compared to room temperature saline swabs. On the other hand, normal saline instillation during suctioning was associated with increased heart rate, respiratory rate, and systolic blood pressure, indicating potential negative effects on oral health. Additionally, using cold normal saline mouthwash was shown to be more effective than tooth brushing alone in improving oral health status and relieving xerostomia in elderly individuals. These findings collectively suggest that cold saline interventions may offer benefits in terms of oral health outcomes for mechanically ventilated patients compared to room temperature saline solutions.Does understanding children psychology important in optometry?

Understanding children's psychology is crucial in optometry. It aids in recognizing their needs, fears, and anxieties at different developmental stages, facilitating the implementation of tailored behavior management techniques for effective dental treatment. In pediatric optometry, establishing a good rapport with children and parents is essential to enhance compliance and cooperation during assessments. Factors such as age, sex, previous negative experiences, and anxiety levels play a role in children's cooperation during eye examinations. Additionally, involving young children in the development of eye tests can lead to improvements in test instructions and overall understanding, showcasing the impact of engaging children in research activities. Therefore, a deep understanding of children's psychology is fundamental in providing high-quality ophthalmic care and ensuring successful eye examinations in pediatric optometry.