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The presence of heparin-like polysaccharide may present entrapment of the schistosoma by the hosts' blood-clotting process.
Those factors not only affect the development and elimination of Schistosoma mansoni, but also the pathology triggered by infection with this parasite.
This study represents the first report about the binding of plasminogen to Schistosoma sp.
Generalization of the results to all Schistosoma species may be difficult as in the study presented here only eggs of S. mansoni were detected by microscopy.

Related Questions

Literature review on intestinal schistosomiasis?5 answersIntestinal schistosomiasis is a neglected tropical parasitic disease caused by trematode worms of the genus Schistosoma. It affects approximately 240 million people worldwide. The diagnosis of the disease can be performed using parasitological, molecular, and/or immunological methods. However, the development of new diagnostic methods is still essential to guide policy decisions, monitor disease trends, and assess the effectiveness of interventions. Serology-based diagnostic methods, such as enzyme-linked immunosorbent assay (ELISA) tests, have been explored for the detection of schistosomiasis antigens. In Brazil, serology tests, including immunofluorescent antibody tests (IFATs) and ELISAs, have been used for population screening in low endemicity settings. There is a need for more sensitive diagnostic methods to aid in the elimination of schistosomiasis, especially in urban and peri-urban areas where transmission hotspots still exist. Further research is required to improve control interventions and reduce the risk of initial infection and reinfection in endemic areas.
What is the prevalence of Schistosomiasis?3 answersThe prevalence of schistosomiasis varies across different studies and populations. In Northwestern Ethiopia, the prevalence of Schistosoma mansoni was found to be 10.4%. A meta-analysis of studies worldwide reported a pooled prevalence of S. haematobium at 13.44 per 100 observations and S. mansoni at 12.18 per 100 observations among pregnant women. In a community near a dam in Nigeria, the overall prevalence of schistosomiasis was 20.3%, with urinary schistosomiasis at 12.3% and intestinal schistosomiasis at 8%. In a non-endemic area of Ghana, the prevalence of urinary schistosomiasis was 34.6% among the study participants. In rural northwestern Madagascar, the prevalence of schistosomiasis was recorded at 64.47% using a combination of diagnostic methods. These findings highlight the varying prevalence rates of schistosomiasis in different regions and populations, emphasizing the need for targeted control and prevention strategies.
What is intracellular trafficking?5 answersIntracellular trafficking refers to the process by which molecules and organelles are transported within cells. It involves the movement of these components from one location to another, such as from the cell membrane to the nucleus or from the cytoplasm to the lysosomes. The mechanisms underlying intracellular trafficking are complex and involve various pathways and organelles. For example, in B cells, internalized antigens are trafficked along the endosomal pathway, from early to late endosomes, and eventually to a perinuclear compartment rich in lysosomal markers and MHCII. Phosphatidylinositol-4-phosphate (PI4P) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1) play a role in the formation and stability of recycling endosomal tubules. In the context of antibody-based therapeutics, internalization and intracellular trafficking are crucial for the delivery of therapeutic payloads to target intracellular compartments. Intracellular trafficking is also important in the context of phagocytosis, as macrophages undergo a maturation process to create an antimicrobial environment within phagosomes. Additionally, intracellular trafficking is involved in the establishment and maintenance of planar cell polarity, with PCP proteins being transported along the secretory and endocytic transport pathways.
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