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Is sertraline metabolized in the liver? 

Monoamine oxidase B
Microsome
Monoamine oxidase
Desmethylsertraline
Sertraline
Best insight from top research papers

Yes, sertraline is metabolized in the liver. Multiple cytochrome P450 (CYP) isoforms are involved in the metabolism of sertraline, including CYP2B6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 . These enzymes catalyze various metabolic pathways of sertraline, such as N-demethylation and deamination. CYP2C19 plays a significant role in the high-affinity N-demethylation of sertraline, while CYP2C9 contributes to the low-affinity component of this pathway . Additionally, CYP2B6 is identified as the major contributor to sertraline N-demethylation, with lesser contributions from other CYP isoforms like CYP2C19, CYP2C9, CYP3A4, and CYP2D6 . The involvement of multiple enzymes suggests that no single agent or genetic polymorphism of a drug-metabolizing enzyme can substantially alter the pharmacokinetics of sertraline .

Answers from top 5 papers

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Papers (5)Insight
Open access•Journal Article
Sertraline Induced Hepatotoxicity: A Case Report and Review of Literature
Mayur Brahmania, Zachary Schwartz, Greg Rosenfeld, Eric M. Yoshida 
31 Dec 2010-The Internet Journal of Gastroenterology
2 Citations
Yes, Sertraline is metabolized in the liver. The paper discusses a case of hepatotoxicity induced by Sertraline, highlighting the importance of monitoring liver function in patients taking this medication.
Open access•Journal Article•DOI
Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes
Zhen-Hua Xu, Wei Wang, Xue-Jun Zhao, Song-Lin Huang, Bing Zhu, Nan He, Yan Shu, Zhao-Qian Liu, Hong-Hao Zhou 
01 Sep 1999-British Journal of Clinical Pharmacology
57 Citations
Yes, sertraline is metabolized in the liver. The enzymes CYP2C19 and CYP2C9 are involved in the N-demethylation of sertraline in human liver microsomes.
Journal Article•DOI
Sertraline Hepatotoxicity: Report of a Case and Review of the Literature
Fehmi Tabak, Feyza Gunduz, Veysel Tahan, Omur Tabak, Resat Ozaras 
01 Jul 2009-Digestive Diseases and Sciences
27 Citations
Yes, sertraline can cause hepatotoxicity, indicating it is metabolized in the liver. However, the exact mechanism of sertraline-induced hepatotoxicity is still debated in the literature.
Open access•Journal Article
Sertraline N-Demethylation Is Catalyzed by Multiple Isoforms of Human Cytochrome P-450 In Vitro
Kaoru Kobayashi, Tomoko Ishizuka, Noriaki Shimada, Yoshitaka Yoshimura, Kunitoshi Kamijima, Kan Chiba 
01 Jul 1999-Drug Metabolism and Disposition
112 Citations
Yes, sertraline is metabolized in the liver through N-demethylation by multiple isoforms of human cytochrome P-450 enzymes, including CYP2B6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4.
Journal Article•DOI
Sertraline is metabolized by multiple cytochrome p450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study
R. Scott Obach, Loretta M. Cox, Larry M. Tremaine 
01 Feb 2005-Drug Metabolism and Disposition
177 Citations
Yes, sertraline is metabolized in the liver by multiple enzymes, including cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases, as identified in an in vitro study on human liver microsomes.

Related Questions

How much sertraline to eat to die.?4 answersIngesting a lethal dose of sertraline can have severe consequences, as seen in cases of overdose. For instance, a 22-year-old woman who consumed 30 tablets (1500 mg) of sertraline with suicidal intent experienced tachycardia, hypertension, and other adverse effects, emphasizing the dangers of overdose. Additionally, a case report highlighted a suicide attempt involving an overdose of sertraline, fluvoxamine, and paroxetine, indicating the potential risks associated with consuming excessive amounts of these medications. Studies on nursing mothers revealed that sertraline can pass into breast milk, raising concerns about potential infant exposure. Furthermore, a fatality was reported due to a lethal sertraline intoxication, underscoring the importance of considering the risks of side effects even with moderate dosages.
What is the molar absorption coefficient of sertraline?5 answersThe molar absorption coefficient of sertraline is not mentioned in the abstracts provided.
Are SSRI related to liver cancer?5 answersSSRIs, or selective serotonin reuptake inhibitors, are commonly prescribed antidepressant medications. While the abstracts provided do not directly address the relationship between SSRIs and liver cancer, they do discuss the potential hepatotoxicity, or liver injury, associated with certain antidepressants. Some antidepressants, such as paroxetine, fluoxetine, and venlafaxine, have been linked to reversible liver injury upon discontinuation of the medication. However, there is no specific mention of SSRIs being associated with liver cancer in the abstracts provided. It is important to note that the abstracts may not cover all relevant research on this topic, so further investigation into the literature is recommended to obtain a comprehensive understanding of the relationship between SSRIs and liver cancer.
What is the efficacy of sertraline in treating frequent urination?5 answersSertraline has been studied for its efficacy in treating frequent urination. One study found no statistically significant difference in nocturnal urinary frequency between individuals on sertraline therapy and those not on therapy. However, another study reported that sertraline treatment resulted in an improvement in cognitive and behavioral status in a patient with Neuro-Behcet's syndrome, which can manifest as frequent urination. Additionally, sertraline was found to have greater efficacy than placebo in preventing relapse or insufficient clinical response in patients with obsessive-compulsive disorder. Furthermore, a clinical trial showed that sertraline significantly reduced the intensity of uremic pruritus, a condition associated with frequent urination in patients with end-stage renal disease. Overall, while the evidence is mixed, sertraline may have some efficacy in treating frequent urination in certain conditions.
Is bromantane metabolized in the liver?5 answersBromantane is metabolized in the liver.
How does citalopram affect metabolism of sugars and lipids?5 answersCitalopram's effect on the metabolism of sugars and lipids is not mentioned in the provided abstracts.

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