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Is the OSCP protein a relevant drug target? 


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The oxysterol-binding protein (OSBP) and its related protein homologs, such as ORP4, have been identified as potential druggable targets in antiviral and cancer drug development, including ovarian cancer treatment . These proteins play crucial roles in lipid homeostasis, membrane integrity, and cellular proliferation, making them attractive targets for precision drug development . Specifically, ORP4 has shown limited expression in normal tissues and is a cancer-specific driver of proliferation, especially in ovarian cancer cells . The discovery of highly potent and selective inhibitors of OSBP, termed oxybipins, further supports the therapeutic relevance of targeting these proteins . Overall, the data suggests that OSBP and its related proteins, including ORP4, are indeed relevant drug targets for the development of novel treatments, particularly in the context of antiviral and cancer therapies.

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OSTP, not OSCP, is a novel peptide targeting human ovarian cancer, showing specificity and potential for diagnostic and drug-targeted therapies, making it a relevant drug target.
Yes, OSBP (oxysterol binding protein) is a relevant drug target as selective inhibition blocks retrograde trafficking, inducing partial Golgi degradation, and attenuating Shiga toxin toxicity, as per the research findings.
Not addressed in the paper.
Yes, ORP4 (Oxysterol-Binding Protein-Related Protein 4) is a potential druggable target in ovarian cancer cells, showing high antiproliferative potency in both monolayer and spheroid models.

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