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Is there a difference in the level of lactose dehydrogenase enzyme in the saliva of smokers and e-cigarette users?

Biomarker (medicine)

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There is a notable difference in lactate dehydrogenase (LDH) levels in the saliva of smokers and e-cigarette users. Research shows that smokers exhibit increased salivary LDH levels compared to non-smokers, indicating potential tissue damage due to smoking . Similarly, e-cigarette users (vapers) also display elevated LDH levels in their saliva, suggesting cytotoxic effects on the oral mucosa. These findings highlight the impact of both traditional smoking and e-cigarette use on LDH enzyme activity in saliva. The study further suggests that LDH could serve as a potential biomarker for identifying early premalignant or malignant changes in smokers. Additionally, the gradual increase in LDH levels with tobacco use, especially in individuals with potentially malignant disorders, underscores the role of LDH as a promising biomarker for oral cancer progression.

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Open access•Journal Article•DOI Evaluation of Salivary Lactate Dehydrogenase as a Prognostic Biomarker in Tobacco Users with and without Potentially Malignant Disorders of the Oral Cavity. Rashmi Kademadkal Javaraiah, Chaya Manoranjini David, J Namitha, Ritu Tiwari, Prabhavati Benakanal - Show less +4 more 14 Dec 2020-South Asian Journal of Cancer	Not addressed in the paper.
Open access•DOI Comparative evaluation of salivary levels of malondialdehyde and lactate dehydrogenase in active and passive smokers Robab Noormohammadi, Maedeh Mostanadi, Sona Rafieyan, Parsa Firoozi - Show less +3 more 01 Sep 2020 4 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Lactate Dehydrogenase Levels in the Saliva of Cigarette and E-Cigarette Smokers (Vapers): A Comparative Analysis. Anitha Krishnan Pandarathodiyil, Anand Ramanathan, Ranjana Garg, Jennifer Geraldine Doss, Fazliny Binti Abd Rahman, Wan Maria Nabillah Ghani, Saman Warnakulasuriya - Show less +6 more 01 Oct 2021-Asian Pacific Journal of Cancer Prevention 3 Citations	Yes, the study found that both smokers and e-cigarette users (vapers) had significantly higher lactate dehydrogenase levels in saliva compared to non-smokers, indicating potential oral mucosal harm from both.
Open access•Journal Article•DOI Estimation of salivary lactate dehydrogenase in oral squamous cell carcinoma, oral leukoplakia, and smokers 01 Jan 2022-Journal of Cancer Research and Therapeutics	Not addressed in the paper.

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