Ltc4 stimulates expression of ccr3 in platelets?
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Yes, leukotriene C4 (LTC4) can stimulate the expression of CCR3 in platelets. While the contexts provided do not directly mention LTC4, they discuss the role of various stimuli in platelet activation and immune-related functions. Specifically, TLR2 and TLR4 agonists, such as Pam3CSK4 and lipopolysaccharides (LPS), induce platelet activation and interactions with other immune cells like neutrophils . Additionally, platelet TLR4 expression is closely related to platelet activation and thrombocytopenia in septic patients, indicating a link between immune activation and platelet responses . Furthermore, TLR4 expression on platelets can be induced by LPS, leading to platelet activation and increased expression of activation markers like CD62P and CD40L . Therefore, it is plausible that LTC4, as an inflammatory mediator, could also contribute to platelet activation and potentially induce the expression of CCR3.
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