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Lysine restricted diet에는 뭐가 있어?

Dietary management

Pyridoxine-dependent epilepsy

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A lysine-restricted diet typically includes specific dietary modifications aimed at managing various conditions such as pyridoxine-dependent epilepsy (PDE) and hyperlysinaemia. In the context of PDE, lysine restriction has been shown to be safe and beneficial, leading to partial normalization of lysine intermediates in body fluids and potentially improving seizure control and psychomotor development . Additionally, lysine restriction is crucial in cases of hyperlysinaemia, where dietary management plays a significant role in controlling the condition . The importance of an adequate amino acid mixture in the diet is highlighted, as it supports protein synthesis and helps maintain high levels of O 6 -methylguanine-DNA methyltransferase (MT) for DNA lesion repair during exposure to alkylating agents . Therefore, a lysine-restricted diet typically involves careful monitoring and adjustment of lysine intake to manage specific metabolic disorders effectively.

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Open access•Journal Article•DOI Lysine-restricted diet and mild cerebral serotonin deficiency in a patient with pyridoxine-dependent epilepsy caused by ALDH7A1 genetic defect. Saadet Mercimek-Mahmutoglu, Dawn Corderio, Laura Nagy, Carly Mutch, Melissa T. Carter, Eduard A. Struys, Lianna Kyriakopoulou - Show less +6 more 01 Jan 2014-Molecular genetics and metabolism reports 21 Citations	Lysine-restricted diet for pyridoxine-dependent epilepsy includes reduced lysine intake to manage ALDH7A1 genetic defect, aiming to decrease α-AASA levels, but may lead to mild cerebral serotonin deficiency.
Journal Article•DOI Combined effect of dimethylnitrosamine and a lysine-restricted diet on O6-methylguanine-DNA methyltransferase levels in mouse tissues Maria Klaude, Gisela Persson, Alexandra von der Decken - Show less +2 more 01 Sep 1989-Mutation Research-dna Repair	Lysine-restricted diet reduces O6-methylguanine-DNA methyltransferase levels in mouse tissues, intensifying with dimethylnitrosamine exposure, emphasizing the importance of adequate lysine for protein synthesis and DNA repair.
Open access•Book Chapter•DOI Lysine-Restricted Diet as Adjunct Therapy for Pyridoxine-Dependent Epilepsy: The PDE Consortium Consensus Recommendations Clara D.M. van Karnebeek, Sylvia Stockler-Ipsiroglu, Sravan Jaggumantri, Birgit Assmann, Peter Baxter, Daniela Buhas, Levinus A. Bok, Barbara Cheng, Curtis R. Coughlin, Anibh M. Das, Alette Giezen, Wahla Al-Hertani, Gloria Ho, U. Meyer, Philippa B. Mills, Barbara Plecko, Eduard A. Struys, Keiko Ueda, Monique Albersen, Nanda Verhoeven, Sidney M. Gospe, Renata C. Gallagher, Johan Van Hove, Hans Hartmann - Show less +23 more 19 Apr 2014 42 Citations	A lysine-restricted diet for pyridoxine-dependent epilepsy includes monitoring lysine intermediates, amino acids in plasma, and lifelong pyridoxine-HCl treatment adherence for safety and efficacy.
Open access•Journal Article•DOI Dietary treatment of hyperlysinaemia. John Gregory, N. Beail, N. A. Boyle, C. Dobrowski, P. Jackson - Show less +4 more 01 May 1989-Archives of Disease in Childhood 16 Citations	A lysine restricted diet for hyperlysinaemia involves limiting lysine intake. The success of such diets varied among siblings with unpredictable outcomes, suggesting potential benefits in managing this rare disorder.

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Lysine is safe to take,?5 answersBased on the research presented in various studies, including a systematic review of l-lysine safety, it has been found that lysine is generally safe for consumption within recommended doses. The provisional no-observed-adverse-effect level for l-lysine in healthy human subjects was identified at 6.0 g/day, primarily based on gastrointestinal symptoms. High doses of lysine, ranging from 10-30g/day, may lead to abdominal cramps and diarrhea, but renal and hepatic toxicity is not commonly reported in normal individuals. Additionally, NOAELs for supplemental lysine at 6.0 g/day have been proposed for healthy adults, specifically when administered in fortified foods or dietary supplements. Furthermore, lysine has shown positive effects in diabetic patients, improving glycemic control and antioxidant markers without causing liver or kidney toxicity. Therefore, when taken within recommended limits, lysine appears to be safe for consumption.

Why lysine promotes HIV?4 answersLysine promotes HIV-1 in different ways. The bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50, competing against HIV-1 TAR RNA binding to the acetylated Tat. Lysine residues (K25) at the base of the HIV capsid pore play a crucial role in HIV infection and DNA synthesis. Inositol phosphates coordinate a ring of positively charged lysine residues, and their removal severely inhibits HIV infection and prevents DNA synthesis. Lysine mutations in the HIV-1 Vif protein affect its expression and viral infectivity. While some lysines are important for Vif expression, others are essential for viral growth in non-permissive cells. The direct effect of L-lysine amino acid on HIV-1 RNA replication in vitro has not been well-documented, but amino acids are known to play a role in virus replication and gene expression.

What is l lysine supplementation?4 answersL-lysine supplementation refers to the addition of L-lysine, an essential amino acid, to the diet or as a dietary supplement. L-lysine has been studied for its effects on various aspects of health and metabolism. In the context of type 2 diabetes, L-lysine supplementation has been shown to improve glycemic control, inhibit protein glycation, and increase antioxidant markers. However, excessive L-lysine supplementation may have adverse effects, such as altered body weight, food intake, and hematological and biochemical parameters, especially when combined with a low protein diet. In terms of mineral bioavailability, L-lysine supplementation at relatively high levels does not appear to affect copper or iron bioavailability in rats. Additionally, L-lysine supplementation has been studied in the context of lysine-related inborn errors of metabolism, where it is used in combination with arginine to competitively inhibit enteral lysine uptake and reduce lysine oxidation. In broilers, L-lysine supplementation has been shown to improve body weight gain, feed consumption, and feed efficiency.

What are the benefits and risks of supplemental lysine?5 answersSupplemental lysine has several benefits and risks. It has been proposed that supplemental lysine at 6.0 g/d has a no observed adverse effect level (NOAEL) for healthy adults when administered in fortified foods or dietary supplements. In patients with lysinuric protein intolerance (LPI), low-dose oral lysine supplementation has been shown to improve fasting plasma lysine concentrations without causing side effects. Lysine supplementation has also been found to have clinical significance in the treatment of various pathological conditions such as herpes simplex virus (HSV) infection, osteoporosis, anxiety, mood disturbances, migraine, Alzheimer's dementia, hair loss, shingles, cancer, cardiovascular diseases, and aging. However, the effects of oral lysine supplementation as prophylaxis or treatment of HSV infections have produced contradictory results in clinical studies. Overall, while lysine supplementation can have potential benefits, it is important to consider individual health conditions and consult with a healthcare professional before starting supplementation.

Does L Lysine have zinc in it?3 answers

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