Relationship between nanoplastics and the organisation of the mouse testis?
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Nanoplastics (NPs) have been shown to impact the organization of the mouse testis. Studies have revealed that exposure to polystyrene NPs disrupts the homeostasis of the gut microbiota and metabolism, leading to male reproductive toxicity. Furthermore, evidence suggests that NPs can accumulate in the gonads, triggering seminiferous degeneration, Sertoli cell death, and disruption of the blood-testis barrier, ultimately affecting sperm quality and hormone levels. Toxicokinetic studies have demonstrated that after oral exposure, NPs are rapidly absorbed in the blood, accumulate in adipose tissues, and penetrate the blood-brain/testis barriers, highlighting the size-dependent toxicokinetics of microplastics in mammals. These findings underscore the significant impact of nanoplastics on the organization and function of the mouse testis, emphasizing the need for further research on the reproductive toxicity of these environmental pollutants.
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| Papers (4) | Insight |
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57 Citations | Not addressed in the paper. |
| Nano-scale polystyrene nanoplastics (PS-NPs) disrupt gut microbiota and metabolites, leading to male reproductive toxicity in mice, affecting sperm parameters and testosterone levels, as per the study findings. | |
01 Jan 2023 | Not addressed in the paper. |
| Nanoplastics can disrupt the organization of the mouse testis by triggering seminiferous degeneration, Sertoli cell death, and blood-testis barrier disruption, as per preclinical evidence. |
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