Search or ask a question

What are some of the recommended books on companion diagnostics?

Medical biology

Molecular imaging

Companion diagnostic

Best insight from top research papers

Companion diagnostics is a fast-evolving area of medical research that plays a central role in the development of targeted drugs. The success of targeted therapy depends on the performance of companion diagnostic assays, which provide information necessary for safe and effective use of therapeutic products . The first generation of companion diagnostic assays relies on single biomarker detection, but a new generation is under development that will be based on patient profiling and multiplex platforms . Molecular imaging using radiolabeled small molecules, peptides, and antibodies has shown potential as a companion diagnostic, allowing evaluation of tumors at both anatomical and molecular levels . As more predictive biomarkers become clinically validated and more targeted therapies become available, multiplex and multiparameter diagnostics will replace single marker companion diagnostics, enabling rapid molecular taxonomy across disease entities . There is a need for accurate companion diagnostics to ensure the right patient selection for targeted therapies .

Answers from top 5 papers

PDF

Open Access

More filters

Papers (5)	Insight
Open access•Journal Article•DOI “Companion Diagnostics”: Has Their Time Come and Gone? Fred R. Hirsch, Paul A. Bunn, Roy S. Herbst - Show less +2 more 01 Sep 2014-Clinical Cancer Research 19 Citations	The provided paper does not mention any recommended books on companion diagnostics.
Journal Article•DOI A perspective analysis: companion diagnostics: an evolving paradigm in 21st century healthcare Martina Kaufmann, Mieke Keppens, Edward D Blair - Show less +2 more 03 Aug 2015-Personalized Medicine 3 Citations	The provided paper does not mention any recommended books on companion diagnostics.
Book Chapter•DOI Molecular Imaging Companion Diagnostics Kathryn M. Tully, Kathryn M. Tully, Nicholas B Sobol, Patrícia M. R. Pereira, Jason S. Lewis - Show less +4 more 01 Jan 2019 2 Citations	The paper does not mention any recommended books on companion diagnostics.
Open access•Journal Article•DOI Companion diagnostics: the key to personalized medicine Jan Trøst Jørgensen 17 Jan 2015-Expert Review of Molecular Diagnostics 38 Citations	The paper does not mention any recommended books on companion diagnostics.
Book Chapter•DOI An Introduction to Companion and Complementary Diagnostics Jan Trøst Jørgensen, Maria Hersom - Show less +1 more 01 Jan 2019 1 Citations	The provided paper does not mention any recommended books on companion diagnostics.

My columns

Related Questions

What is the value of companion diagnostics for cancer management?5 answersCompanion diagnostics (CDx) have significant value in cancer management. CDx assays aid in the identification of patients eligible for targeted therapies and predict patient responses to these therapies. They also play a crucial role in patient selection for clinical trials, leading to higher response rates when the right patients are chosen. CDx testing coupled with biomarker-driven treatment offers a greater survival benefit for patients with advanced non-small cell lung cancer (NSCLC). Patients with NSCLC who underwent CDx testing had a reduced mortality risk and lived longer than those without testing. CDx testing is particularly important in the field of oncology therapeutics, where it accelerates the introduction of new therapeutics and reduces the number of patients exposed to investigational or approved drugs. The development of CDx assays is essential for realizing the full therapeutic potential of targeted cancer drugs.

Why people need companion when traveling?5 answersPeople need companions when traveling because the right travel partner can enhance the trip experience and help overcome challenges and frustrations. Additionally, traveling with companions can provide a sense of safety and security, especially in unfamiliar or potentially dangerous environments. Companions can also offer emotional support and companionship, making the journey more enjoyable and memorable. Furthermore, companions can help with practical aspects of travel, such as sharing expenses, navigating unfamiliar places, and providing assistance in case of emergencies. Overall, traveling with companions can make the trip more fulfilling, enjoyable, and less stressful.

Is it better to travel with companion?5 answersTraveling with a companion can have both advantages and disadvantages. On one hand, having the right travel partner can make the trip more enjoyable and less challenging. It can also help in reaching the destination according to plan. On the other hand, traveling with the wrong companion can increase the challenges and frustrations of the trip. Additionally, when traveling with a group, it is important to agree on roles and responsibilities beforehand to avoid any issues during the journey. Overall, the decision to travel with a companion depends on personal preferences and the dynamics of the relationship with the potential travel partner.

Can people with autisme benefit from AI companion?5 answersPeople with autism spectrum disorder (ASD) can potentially benefit from AI companions. Research suggests that robot-based interventions and animal-assisted interventions (AAI) have shown positive impacts on the social behaviors of children with ASD. Additionally, technological agents such as humanoid robots and avatars have been found to increase motivation and response to social bids in young children with ASD. While research on the potential of deepfakes as an assistive technology for people with autism is scarce, developing generative AI-based assistive solutions could have ramifications for human-computer interaction (HCI) and improve social communication and interactions for individuals with ASD. However, more rigorous research methods are needed to determine the effectiveness of AI companions for individuals with ASD.

What are the types of voice companion?3 answersThere are several types of voice companions mentioned in the abstracts. One type is a photoelectric sound-control type voice accompany book, which is a novel book that emits voice and is designed for children to listen and read. Another type is the Broadway Song Companion, which is a guide to the vast literature of the Broadway musical for solo performers, listing every song from over 210 Broadway shows. The Singer's Companion is a guide to improving one's voice and performance, designed for singing teachers and students in the classical, music theater, and pop genres. New developments in voice and facial video generation suggest the possibility of audio and visual interactive companionship, which can be used for entertainment, therapy, training, and more. Finally, a family peer-based intervention called In Our Own Voice-Family Companion (IOOV-FC) is designed to reduce self-stigma among family members of people with serious mental illness.

What are interesting books to learn medicine?5 answersThere are several interesting books to learn medicine. One book is a collection of sketches of 10 physicians whose lives profoundly influenced medical procedures and our quest for knowledge. It offers a refreshing bedside reading and is a splendid introduction for students interested in medicine. Another book discusses different aspects of medicine, including bedside medicine, library medicine, hospital medicine, social medicine, laboratory medicine, and technological medicine. Additionally, there is a book that explores a new medical school in Long Island that claims to be doing things differently and better. Lastly, there is a book that focuses on the intravital technique and its findings in diseases such as myasthenia gravis and dystrophia myotonica, indicating a new phase of investigation in mysterious maladies.

See what other people are reading

What was the statistics of breast cancer in 2023?

In 2023, the American Cancer Society projected 1,958,310 new cancer cases and 609,820 cancer deaths in the United States, with breast cancer being a significant concern. Breast cancer has shown a steady increase in incidence rates over the past four decades, with a 0.5% annual rise from 2010 to 2019, primarily driven by localized-stage and hormone receptor-positive disease. Despite the increase in incidence, breast cancer mortality rates have been declining, albeit at a slower pace in recent years, with a 1.3% annual decrease from 2011 to 2020. Racial disparities persist in breast cancer mortality, with Black women experiencing a 40% higher death rate compared to White women. The progress against breast cancer mortality could be accelerated by addressing these disparities through improved access to screening and treatment.What is the overall survival rate of ER Her2- breast cancer?

The overall survival rate of ER+HER2- breast cancer varies based on different factors. In young ER+HER2- breast cancer patients, primary tumor characteristics like lymph node metastasis and histologic grade significantly impact long-term survival after developing distant metastasis (DM). HER2-low breast cancer, which represents a potential therapeutic target, shows better breast cancer-related overall survival compared to HER2-0, with ER status and nodal involvement playing crucial roles in prognosis. For ER+HER2- breast cancers, the prognostic role of HER2 expression is more pronounced in ER-high tumors, while lower ER expression is not significantly associated with HER2 status in terms of overall survival. Adherence to treatment guidelines in HER2-positive metastatic breast cancer patients leads to a significantly higher median overall survival, with ER-negative disease and high tumor burden posing higher risks of developing brain metastases.What are the current imaging modalities used for brain metastasis detection?

The current imaging modalities used for brain metastasis detection include computed tomography (CT) and magnetic resonance imaging (MRI). Advanced imaging techniques such as proton magnetic resonance spectroscopy, magnetic resonance perfusion, diffusion weighted imaging, and diffusion tensor imaging are also utilized to aid in accurate diagnosis, especially in cases of solitary enhancing brain lesions in patients without known malignancy. Additionally, molecular imaging with positron emission tomography (PET) using various agents like 18F-fluorodeoxyglucose (18F-FDG), prostate specific membrane antigen (PSMA) ligands, alkylphosphocholine analogs, and amino acids can help identify brain metastases and improve diagnostic accuracy. Quantitative MRI techniques like diffusion-weighted imaging (DWI), dynamic susceptibility contrast (DSC), arterial spin labeling (ASL), and dynamic contrast-enhanced (DCE) are potential biomarkers for diagnosing metastases recurrence and radioresistance.What was the pipeline that led to discovery of lapatinib?

The discovery of lapatinib, a dual EGFR and ERBB-2 tyrosine kinase inhibitor, involved a carefully designed biological evaluation cascade coupled with multidimensional data analysis. Lapatinib was initially identified as a multitargeted inhibitor of phosphoprotein signaling in Trypanosoma brucei, despite lacking EGFR-like tyrosine kinases, through proteome-wide phosphopeptide analysis and affinity chromatography studies. Lapatinib's efficacy against HER2-amplified breast cancer was further explored, showing activity in trastuzumab-refractory cases and in combination with letrozole for ER-positive, HER2-positive breast cancer. However, lapatinib exhibited limited activity against the xenografts of the Pediatric Preclinical Testing Program (PPTP) in vivo panel, suggesting differences in therapeutic targets between adult and pediatric cancers.How does PBC impact cardiac function?

PBC (Primary Biliary Cholangitis) impacts cardiac function by potentially leading to cardiac-related deaths, especially in patients with systemic fatigue. Studies have shown that PBC patients with severe fatigue exhibit changes in cardiac function, such as increased cardiac torsion and decreased circumferential strain, indicating impaired subendocardial myofibre function. Additionally, exposure to lead ions (Pb2+) has been linked to cardiotoxic effects, reducing cardiac contractility and increasing the risk of arrhythmias. Furthermore, breast cancer patients undergoing potentially cardiotoxic therapies are at risk of cardiotoxicity, with a substantial burden of cardiac dysfunction over time, especially when combined with cardiovascular risk factors like hypertension, obesity, and dyslipidemia. Monitoring cardiac function in PBC patients and those exposed to cardiotoxic treatments is crucial for early detection and management of cardiac complications.Does NonPCR Need Intensive Treatment in Neoadjuvant Chemotherapy of breast cancer?

Non-pathological complete response (NonPCR) in neoadjuvant chemotherapy for breast cancer may require intensive treatment. Studies have shown that the addition of metformin to neoadjuvant chemotherapy significantly improves pathological complete response (PCR) rates in breast cancer patients. Liquid biopsy-based biomarkers, such as non-coding RNAs, have been investigated for their potential to diagnose early responses to neoadjuvant chemotherapy, allowing for timely adjustments in therapy regimens. Achieving PCR following neoadjuvant chemotherapy is associated with better prognosis, but nearly half of patients may not reach PCR. Therefore, strategies to enhance PCR rates, such as incorporating taxanes, dual anti-HER2 therapy, or immunotherapy, may be crucial for improving outcomes in patients with NonPCR in neoadjuvant chemotherapy for breast cancer.How does screening proves lapatinib better than other classes of drugs?

Screening studies have demonstrated the superiority of lapatinib over other classes of drugs in various therapeutic contexts. In the context of SARS-CoV-2, a high-throughput drug repurposing screen identified lapatinib as a potent antiviral agent, inhibiting viral replication significantly without toxicity, even when combined with other drugs like doramapimod. In HER2+ breast cancer, lapatinib in combination with trastuzumab showed substantial effects on cell viability, particularly when combined with dasatinib, indicating its efficacy in targeted therapy. Furthermore, in malaria research, lapatinib exhibited strong activity in inhibiting β-haematin formation and parasite growth, outperforming other drugs like nilotinib and lomitapide. These findings collectively highlight lapatinib's effectiveness across different diseases and its potential as a promising therapeutic option in various treatment regimens.Is caspase 3 a good marker for apoptosis?

Yes, Caspase-3 is a valuable marker for apoptosis in various contexts. Research shows that Caspase-3 is crucial in apoptosis and is considered a biomarker for cell apoptosis. Studies on colorectal carcinomas (CRC) indicate that high Caspase-3 expression correlates with favorable clinicopathological features and acts as a potential prognostic factor, suggesting its role as a tumor suppressor in CRC. Additionally, in breast cancer patients, Caspase-3 expression did not directly correlate with traditional prognostic markers but showed potential as a prognostic biomarker for future use. Furthermore, pan-cancer analyses reveal that CASP3 expression is significantly associated with cancer prognosis in various tumors, indicating its potential as a prognostic marker across different cancer types. Overall, Caspase-3 emerges as a promising marker for apoptosis with implications in cancer diagnosis, prognosis, and therapeutic monitoring.Issues not covered in that article? What questions are not answered?

The articles provided cover a wide range of topics in cancer research, but there are still some questions left unanswered. One such question pertains to the impact of pregnancy recency on tumor molecular features in breast cancer, as highlighted by Vohra et al.. Additionally, the potential disparities in cancer mortality among diverse Asian American ethnicities remain unexplored, emphasizing the need for further investigation as indicated by Karia et al.. Furthermore, the assessment of the burden of potentially modifiable cardiometabolic risk factors among childhood cancer survivors treated with anthracycline-containing regimens, compared to controls, raises questions about optimal risk assessment and management strategies, as discussed by Lipshultz et al.. These gaps in knowledge underscore the importance of continued research to address these critical issues in cancer care and outcomes.What are Extent of integration of the interdisciplinary approach in science in terms of Content?

The extent of integration of the interdisciplinary approach in science, particularly in terms of content, is crucial for enhancing the educational experience and professional competence of students. Various studies emphasize the significance of interdisciplinary integration in teaching fundamental disciplines like histology, cytology, embryology, human anatomy, bioorganic and biological chemistry, and medical biology. This integration not only deepens knowledge but also improves cognitive skills, clinical thinking, and problem-solving abilities. Implementing interdisciplinary integration in educational programs helps in forming a holistic scientific worldview, overcoming fragmentariness, and promoting spatial representations based on the natural science picture of the world. The use of innovative forms and methods of integration, along with digital educational resources, plays a vital role in enhancing interdisciplinary interaction in educational settings.Amidst uncertainty regarding treatment during convid thee was heavly reliance on home remedies world including india

During the COVID-19 pandemic, there was a significant reliance on home remedies globally, including in India, due to uncertainties surrounding treatment options. Home remedies were widely used as a form of self-care and treatment for minor illnesses during lockdowns and restrictions on movement. In countries like India, where traditional medicine practices are deeply rooted, home remedies have been a common practice for generations, especially among women, for quick relief and prevention of illnesses. The use of natural remedies, such as Ayurvedic Kadha, was prevalent among individuals seeking alternative treatments during the pandemic. The affordability, accessibility, and cultural acceptance of home remedies made them a popular choice for individuals who faced challenges in accessing conventional medical care.