What are the current advancements in the development of nanoparticle loaded transdermal patches for drug delivery?4 answersCurrent advancements in nanoparticle-loaded transdermal patches for drug delivery involve overcoming skin barriers to enhance drug absorption. Nanoparticles, particularly lipid nanosystems and PLGA nanoparticles, are being utilized to improve skin permeability and drug release. These innovative delivery systems offer controlled release, targeted delivery, and increased bioavailability, making them promising alternatives to conventional drug administration routes. By combining nanoparticles with microneedle array patches (NPs@MAPs), researchers aim to enhance drug penetration through the skin. The development of nanoparticle-loaded transdermal patches not only provides efficient drug delivery but also offers benefits such as prolonged therapeutic effects, adaptability, and reduced toxicities. These advancements signify a significant step towards enhancing patient compliance and treatment outcomes in the field of transdermal drug delivery.
Are magnetic particles expected to be used as carriers for drug delivery?5 answersYes, magnetic particles are anticipated to be extensively utilized as carriers for drug delivery due to their advantageous properties. These particles can be directed towards specific areas in the body using external magnetic fields, enabling targeted drug delivery. Magnetic nanoparticles (MNPs) have garnered attention for their biocompatibility, low toxicity, and responsiveness to magnetic fields, making them ideal candidates for drug delivery systems. Recent advancements highlight the potential of magnetic nanoparticles in developing targeted drug delivery systems, especially in cancer treatment, by combining imaging and therapeutic modalities for precise drug release at specific sites. Smart magnetic nanocarriers have been designed to achieve controlled drug release and localized hyperthermia, showcasing their potential for cancer treatment. Additionally, organic-modified magadiite-magnetic nanocomposite particles have shown promise as efficient drug carriers with sustained release and targeted delivery properties.
What are the current advancements in the application of nanotechnology for the delivery of plant-based medicines?5 answersCurrent advancements in the application of nanotechnology for delivering plant-based medicines are significant. Nanotechnology has enabled the development of novel strategies to enhance the bioavailability and effectiveness of phytochemical components. Specifically, in the treatment of inflammatory bowel disease (IBD), synthetic nanoparticles and extracellular vehicles (EVs) derived from medicinal plants are being utilized to deliver active phytochemicals to the colon, aiding in anti-inflammation and regulation of oxidative stress. Moreover, nanotechnology is being applied to genetic manipulation in plants, facilitating direct germline editing and modification of plant genomes through nanocarriers. Additionally, nanocarriers such as polymeric nanoparticles, nanoliposomes, and dendrimers are being researched for delivering phyto active components to brain tissue, offering potential benefits in treating brain disorders like Parkinson's and Alzheimer's disease.
What are the recent advancements in polymer-based drug delivery systems?5 answersRecent advancements in polymer-based drug delivery systems include the development of innovative drug delivery systems with improved therapeutic efficacy. Polymer-based gels have shown attractive properties and have raised the attention of pharmaceutical scientists, with stimuli-responsive gels being among the most studied. Coordination polymers, especially metal organic frameworks (MOFs), have demonstrated outstanding performance in drug delivery and are increasingly being used as drug delivery systems. Polymeric micelles have been found to improve drug absorption and protect loaded drug substances from the gastrointestinal system's hostile conditions, making them effective for oral drug delivery. Natural polymer-based transdermal drug delivery (TDD) systems have shown great potential in tumor therapy, with the ability to deliver drugs to tumor sites and release them in response to specific stimuli. Atom transfer radical polymerization (ATRP) has enabled the precise design and preparation of nanostructured polymeric materials for drug delivery, including smart drug delivery systems that can release bioactive materials in response to external stimuli.
Explain the magnet property in magnetic drug delivery for carotid artery?5 answersMagnetic drug delivery in the carotid artery utilizes the magnetic property to guide therapeutic agents to the desired location. The agents are bonded to superparamagnetic iron oxide nanoparticles (SPIONs) and are guided through a magnetic field. The magnets are strategically placed adjacent to the artery wall to steer the SPIONs towards the target lesion and prevent entry into unwanted outlets. The configuration of the magnets plays a crucial role in the drug delivery efficiency, and areas with lower oscillatory shear index (OSI) values are more suitable for magnet placement. Increasing the diameter of the particles does not necessarily result in higher drug delivery efficiency. The magnetic field influences the absorption efficiency and the release of particles from different parts of the artery. The effectiveness of magnetic drug delivery is influenced by factors such as blood flow rheology, viscosity, and the presence of atherosclerotic plaques. The distance between the magnet and the blood vessel also affects nanoparticle capture rate.
Who did the magnetic drug delivery for the first time?5 answersMagnetic drug delivery was first done by ###Kirsten M. Pondman et al.###.