What are the current research efforts aimed at understanding the role of tumor-infiltrating immune cells in cancer immunotherapy?
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Current research efforts are focused on understanding the role of tumor-infiltrating immune cells (TIICs) in cancer immunotherapy. TIICs, such as tumor-associated myeloid cells (TAMCs) and tumor infiltrating lymphocytes (TILs), have been found to play a significant role in the tumor microenvironment and the efficacy of immune checkpoint blockade . Studies have shown that the origin of TAMCs is not limited to myeloid-biased differentiation in the bone marrow, but also includes abnormal differentiation of splenic hematopoietic stem and progenitor cells, erythroid progenitor cells, B precursor cells, and embryo-derived TAMCs . TILs, on the other hand, reflect the local tumor microenvironment and have been proposed as a superior endpoint in cancer vaccination trials . Various immunotherapy strategies, including immune checkpoint blockade, adoptive cell therapies, chimeric antigen receptor T cells, and monoclonal antibodies, have been developed to target TIICs and improve the clinical outcome of tumor patients . Additionally, the use of imaging methods, such as ultrasonography, magnetic resonance imaging, and positron emission tomography-computed tomography, has been explored to assess the level of TILs in different cancer types .
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| Papers (4) | Insight |
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2 Citations | The paper discusses various immunotherapy strategies for tumor-infiltrating immune cells, including immune checkpoint blockade, adoptive cell therapies, chimeric antigen receptor T cells, and monoclonal antibodies. |
| The paper discusses the use of tumor infiltrating lymphocytes (TILs) as an endpoint in cancer vaccine trials, but it does not specifically mention current research efforts aimed at understanding the role of tumor-infiltrating immune cells in cancer immunotherapy. | |
| The provided paper discusses the assessment of tumor infiltrating lymphocytes (TILs) using various imaging methods, but it does not specifically mention current research efforts aimed at understanding the role of TILs in cancer immunotherapy. | |
| The provided paper focuses on the origin and heterogeneity of tumor-associated myeloid cells (TAMCs) in cancer immunotherapy, but does not specifically address current research efforts aimed at understanding the role of tumor-infiltrating immune cells in cancer immunotherapy. |
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