Search or ask a question

What are the effects of ghrelin receptor agonists on feed consumption in animals?

Growth hormone secretagogue

Growth hormone secretagogue receptor

Best insight from top research papers

Ghrelin receptor agonists have been shown to have various effects on feed consumption in animals. In rodent models, ghrelin agonism increased food intake without inducing conditioned taste aversion . Chronic treatment with ghrelin receptor inverse agonists reduced food intake and body weight in diet-induced obese mice . Additionally, ghrelin receptor agonists increased food intake in healthy rats and protected against body weight loss in tumor-bearing rats . These findings suggest that ghrelin receptor agonists can modulate feed consumption in animals, potentially offering therapeutic benefits for conditions such as obesity-related metabolic disorders and cancer anorexia-cachexia syndrome .

Answers from top 4 papers

PDF

Open Access

More filters

Papers (4)	Insight
Open access•Journal Article•DOI Capromorelin: a ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs. Linda Rhodes, Bill Zollers, Jessica A. Wofford, Ernst Heinen - Show less +3 more 01 Feb 2018 22 Citations	The paper states that ghrelin receptor agonists, such as capromorelin, have been studied for their effects on increasing appetite and food intake in animals.
Open access•Journal Article•DOI The effect of a pharmaceutical ghrelin agonist on lifespan in C57BL/6J male mice: A controlled experiment Kathryn A. Kaiser, Inga Kadish, Thomas van Groen, Daniel L. Smith, Stephanie L. Dickinson, Beate Henschel, Erik Parker, Andrew W. Brown, David B. Allison - Show less +8 more 03 Feb 2023-Aging Cell 1 Citations	The paper states that prior studies using ghrelin agonists show greater food intake but does not provide specific information on the effects of ghrelin receptor agonists on feed consumption in animals.
Open access•Journal Article•DOI The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats Tito Borner, Laura Loi, Claudio Pietra, Claudio Giuliano, Thomas A. Lutz, Thomas Riediger - Show less +5 more 01 Jul 2016-American Journal of Physiology-regulatory Integrative and Comparative Physiology 28 Citations	The effects of ghrelin receptor agonists on feed consumption in animals include increased food intake and protection against body weight loss.
Open access•Journal Article•DOI Ghrelin and its role in animals Vinu M Nampoothiri 01 Jan 2021 1 Citations	The effects of ghrelin receptor agonists on feed consumption in animals are not mentioned in the provided paper.

My columns

Related Questions

User do synoviocytes / Fibroblasts express the ghrelin receptor GHS-R?5 answersSynoviocytes and fibroblasts do express the ghrelin receptor GHS-R. Studies have shown that GHS-R is expressed in synoviocytes, where interactions with immune cells can influence cytokine production, including IL-23 and IL-17. Additionally, research on cutaneous neurofibromas found that GHS-R expression was detected in these tumors, with larger neurofibromas showing higher GHS-R expression levels. Furthermore, in vitro experiments with MH7A synovial cells demonstrated that ghrelin can induce apoptosis through caspase signaling pathways, indicating the presence of GHS-R on these cells. Overall, the evidence suggests that both synoviocytes and fibroblasts express the ghrelin receptor GHS-R, highlighting its potential role in various physiological and pathological processes.

Is ghrelin associated with Alzheimer’s disease?5 answersGhrelin is associated with Alzheimer's disease (AD) as indicated by multiple studies. Serum levels of ghrelin and acylated ghrelin (AG) have been found to be altered in AD patients and individuals with mild cognitive impairment (MCI). AD and MCI patients tend to have decreased serum levels of ghrelin, while AG levels are significantly higher in these patients compared to normal controls. Treatment with ghrelin or its agonist has shown attenuation of AD-related pathology, suggesting its therapeutic potential for AD. Metabolic profiling studies have also demonstrated the role of ghrelin in improving memory and cognitive abilities in AD models. Additionally, higher levels of plasma acyl ghrelin and altered DNA methylation and mRNA expression of ghrelin-related genes have been observed in AD subjects. These findings support the association of ghrelin with AD and its potential as a biomarker and therapeutic target for the disease.

What are the effects of ghrelin in birds?5 answersGhrelin has been found to play a role in regulating food intake and migratory behavior in birds. Studies have shown that ghrelin levels in birds reflect their body condition, with higher levels observed in birds with larger fat stores. Manipulating ghrelin levels through injections has also been shown to affect food intake and migratory restlessness in birds. However, the effects of ghrelin on feeding behavior in birds are still not fully understood, as central ghrelin has been found to inhibit food intake when injected, while the effects of peripheral ghrelin are equivocal. Additionally, the motor-stimulating action of ghrelin in the gastrointestinal tract varies among different species of birds, with contraction observed in chickens but not in Japanese quail. Overall, ghrelin appears to play a role in regulating appetite and migratory behavior in birds, but further research is needed to fully understand its effects.

Does leptin suppression of ghrelin responses play a role in the regulation of food intake?5 answersLeptin and ghrelin are two hormones that play a major role in the regulation of food intake. Leptin is secreted from brain tissues and suppresses food intake, while ghrelin is secreted from the proventriculus and stimulates food intake. The relationship between leptin and ghrelin in the regulation of food intake is still evolving, but there is evidence to suggest that leptin may suppress ghrelin responses. In a study with mice, dopamine receptor blockade had no effect on the acute hypophagic effect of ghrelin, suggesting that dopaminergic pathways do not play a role in ghrelin-dependent feeding regulation. Additionally, the PVN-microinjection of glucose increased food intake and stimulated plasma ghrelin levels, indicating a potential interaction between glucose, ghrelin, and food intake regulation. Further research is needed to fully understand the mechanisms by which leptin and ghrelin interact in the regulation of food intake.

The GLP-1 receptor agonists (GLP-1RAs), how do they reduce body weight?5 answersGLP-1 receptor agonists (GLP-1RAs) reduce body weight through their mechanism of action. They not only lower haemoglobin A1c levels but also promote weight loss. The exact molecular mechanisms of how GLP-1RAs reduce body weight are not fully understood, but it is believed that they affect physiological pathways relevant to type 2 diabetes, obesity, and their related comorbidities. GLP-1RAs have been shown to have anti-inflammatory properties and can modulate the immune system, which may contribute to their weight-reducing effects. Additionally, GLP-1RAs have been found to reduce the incidence of cardiovascular events, improve general cognition, and slow the progression of diabetic kidney disease, all of which may indirectly contribute to weight loss. Further research is needed to fully understand the mechanisms by which GLP-1RAs reduce body weight.

What are the potential side effects of GLP-1 agonists?5 answersGLP-1 agonists have potential side effects, including gastrointestinal issues such as nausea and vomiting. Some patients may experience limiting side effects, particularly gastrointestinal, which may lead to cessation of treatment. There are also contraindications for GLP-1 agonists, such as a history or family history of medullary carcinoma of the thyroid, pancreatitis, or during pregnancy. Additionally, when patients stop taking these medications, most will experience rebound weight gain, regaining two-thirds of the weight initially lost over a 12-month period. Furthermore, a study found an increased risk of all thyroid cancer and medullary thyroid cancer with the use of GLP-1 agonists, particularly after 1 to 3 years of treatment.

See what other people are reading

How does insufficient sleep relate to obesity?

Insufficient sleep is closely linked to obesity through various mechanisms. Research indicates that insufficient sleep disrupts appetite hormones, leading to increased hunger, energy intake, and body weight gain. Additionally, inadequate sleep is associated with more sleep disturbances and longer awake time, contributing to higher body mass index (BMI) and obesity risk factors. Studies have shown that children with both obesity and insufficient sleep are more likely to develop cardiometabolic disorders, emphasizing the importance of addressing these co-existing health issues early on. Furthermore, a systematic review in Chinese adults found that a short sleep duration was significantly associated with the development of central obesity, highlighting the impact of insufficient sleep on weight gain in different populations. Overall, insufficient sleep plays a significant role in promoting obesity through hormonal, behavioral, and metabolic pathways.What are the outcomes of using saffron as a treatment for ADHD compared to other pharmacological treatments?

Saffron has shown promising results as a treatment for ADHD when compared to other pharmacological treatments. Studies have demonstrated that saffron extract is effective in treating ADHD symptoms, with results comparable to methylphenidate. Combining saffron with methylphenidate has been found to be more effective in reducing symptoms of ADHD compared to using methylphenidate alone. While methylphenidate is effective for inattention symptoms, saffron has shown to be more effective for hyperactivity symptoms. The use of saffron as an adjuvant to Ritalin has been shown to significantly improve symptoms in adults with ADHD. These findings suggest that saffron could be a valuable alternative or complementary treatment option for individuals with ADHD who do not respond well to traditional pharmacological treatments.How does the consumption of carbohydrates and protein affect glycogen resynthesis and recovery compared to consuming only carbohydrates?

Consuming carbohydrates and protein (CHO-P) has been shown to effectively enhance glycogen resynthesis and subsequent exercise performance compared to consuming carbohydrates alone. Studies have demonstrated that CHO-P ingestion promotes an increase in time to exhaustion (TTE) performance with limited recovery time, indicating its efficacy in supporting endurance athletes. However, when it comes to muscle glycogen resynthesis during short-term post-exercise recovery, prioritizing regular carbohydrate intake is crucial for athletes with limited recovery time between consecutive exercise sessions. Co-ingesting protein with carbohydrates is unlikely to significantly enhance the rate of muscle glycogen resynthesis compared to carbohydrates alone. Additionally, post-exercise supplementation with CHO-P has been linked to improved endurance performance, potentially due to differences in nitrogen balance rather than glycogen metabolism or anabolic cell signaling.What are the effects of microdosing LSD?

Microdosing LSD has various effects based on the research findings. It has been observed that microdosing LSD can lead to improved mood on dose days, with no significant long-term enhancements in mood or cognition reported. Additionally, microdosing LSD has been linked to alterations in time perception by reducing the influence of local temporal priors, thereby mitigating temporal under-reproduction biases. Furthermore, individuals who microdose LSD may experience changes in emotional awareness, potentially resulting in decreased emotional diversity, with specific emotions like awe, shame, and joy being affected during microdosing days. Moreover, microdosing LSD has been associated with modifications in sleep patterns, where individuals who microdose may sleep an extra 24.3 minutes per night compared to those on a placebo, without affecting sleep on dosing days.Are people who take supplements more likely to adhere in research trials?

Individuals who take supplements may exhibit varying levels of adherence in research trials. Research suggests that cognitive dysfunction can impact adherence to study protocols, potentially leading to distorted outcomes. Moreover, intentions to use sport supplements can influence responses to interventions, with those intending to use supplements more likely to respond positively. Additionally, older individuals who take more medications, including supplements, may be more likely to use pillboxes for medication management, indicating a potential link between supplement use and adherence behaviors. However, despite the widespread use of vitamin supplements, many trials fail to report results promptly, highlighting issues with compliance and transparency in the supplement research field. Understanding these dynamics is crucial for designing effective research protocols and interventions.What are the results of fortifying Ogi with date seed protein concentrate?

Fortifying Ogi with date seed protein concentrate resulted in significant improvements in various nutritional and functional properties. The enriched mix showed higher protein, fat, crude fiber, ash, bulk density, water absorption capacity, oil absorption capacity, foam capacity, percentage dispersibility, and total phenolic content compared to the control-ogi. Additionally, the date seed protein concentrate exhibited enhanced solubility, emulsion activity/stability, foaming activity/stability, and oil-binding capacity after high-intensity ultrasound treatment, indicating improved functional properties. Furthermore, a randomized controlled trial demonstrated that date kernel supplementation led to decreased HbA1c and fasting plasma glucose levels, particularly benefiting overweight or obese women by improving glycemic control and lipid profiles. These findings collectively highlight the potential of fortifying Ogi with date seed protein concentrate for enhancing nutritional value and functional characteristics.Does PTSD lead to anxiety?

Yes, PTSD can lead to anxiety. Individuals with PTSD often experience symptoms of anxiety, such as fear, hyperarousal, and distress upon trauma reminders. Moreover, PTSD is frequently associated with higher levels of anxiety and depression compared to non-PTSD groups. Cognitive distortions, which are prevalent in PTSD, contribute to increased anxiety levels in individuals with PTSD. Additionally, trauma-informed beliefs, including anxiety sensitivity (AS), tend to decrease during PTSD treatment, indicating a link between PTSD and anxiety-related beliefs. Therefore, PTSD not only involves anxiety symptoms but also exacerbates anxiety levels, highlighting the intricate relationship between PTSD and anxiety disorders.What are the current researches on measles and rubella vaccine microneedle patch ?

Current research on measles and rubella vaccine microneedle patches focuses on enhancing vaccine coverage and stability. Studies demonstrate that microneedle patches offer advantages like simplified administration, increased thermostability, and reduced wastage, potentially increasing vaccination coverage. Excipient screening has identified optimal formulations for maintaining vaccine potency during drying and storage, with pH buffering playing a crucial role. Additionally, innovative needle-free delivery devices like microarray patches are being explored to overcome implementation barriers and improve vaccine delivery in low- and middle-income countries, contributing to global immunization goals. Research also highlights the potential of microneedles to induce a robust immune response, offer pain-free administration, and enable the delivery of particle-based vaccines, showing promise for future vaccine delivery methods.Hat qualitative analyse von Natriumdodecylsulfat Interferenzen mit Spironolacton?

The qualitative analysis of Sodium Dodecyl Sulfate (SDS) does not directly interfere with Spironolactone. Spironolactone, a mineralocorticoid receptor antagonist, was studied in the SPIREN trial involving renal transplant patients. The trial aimed to assess the impact of Spironolactone on renal injury, fibrosis, and function. Results showed that Spironolactone did not improve long-term renal function or proteinuria in transplant patients. While there was a reduction in chrome-EDTA clearance in the Spironolactone group, it was attributed to a reversible hemodynamic effect rather than interference with SDS. Further analysis is needed to determine if Spironolactone can mitigate interstitial fibrosis progression in renal transplant patients.Is Ghrelin Synthesized in the Central Nervous System?

Ghrelin, an orexigenic peptide primarily synthesized in the gastric mucosa, has been traditionally associated with the hypothalamus as its main source in the central nervous system (CNS). However, recent studies have suggested the presence of ghrelin synthesis and effects in various CNS regions beyond the hypothalamus, such as the midbrain, hindbrain, hippocampus, and spinal cord. While some controversy exists regarding the existence of extra-hypothalamic ghrelin-synthesizing neurons, the distribution of ghrelin receptors outside the hypothalamus implies broader regulatory roles for ghrelin in the CNS. Despite inconsistent evidence, it is acknowledged that ghrelin can modulate central neuronal functions, including neurotransmitter release, gene expression, and neuronal survival, indicating a complex and diverse impact on CNS activity.What are the potential side effects or risks associated with using bitter melon for weight loss purposes?

Bitter melon, known for its medicinal properties, has been traditionally used for various health benefits, including weight loss. Studies have highlighted the diverse pharmacological functions of bitter melon, such as antidiabetic, anti-inflammatory, and anti-obesity effects. Research on bitter melon extract's safety profile indicates its non-toxic nature, with no observed adverse effects even at high doses in animal studies. However, caution is advised when using bitter melon for weight loss due to its potential laxative properties, which could lead to gastrointestinal discomfort or diarrhea, especially when consumed in large amounts. Additionally, bitter melon's impact on glucose metabolism and insulin levels should be monitored, as it may affect individuals with prediabetes or diabetes. Regular monitoring and moderation in consumption are recommended to mitigate any potential risks associated with using bitter melon for weight loss purposes.