What are the effects of PCBs on testicular function?
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Polychlorinated biphenyls (PCBs) have been shown to have detrimental effects on testicular function. Exposure to PCBs can lead to testicular injury, reduced sperm quality, and decreased testosterone levels . PCBs can also disrupt hormone levels, including thyroxine and triiodothyronine, leading to persistent hypothyroidism . Additionally, PCB exposure can downregulate the expression of proteins involved in testosterone biosynthesis, such as P450(17alpha) and P450(scc), further impacting testicular steroidogenesis . The toxic effects of PCBs on testicular function are thought to be mediated through oxidative stress and apoptosis . PCBs can induce reactive oxygen species, causing oxidative stress in the testes and leading to testicular dysfunction . Overall, PCB exposure has been shown to have negative effects on various aspects of testicular function, including spermatogenesis, steroidogenesis, and the function of Sertoli and Leydig cells .
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| The effects of PCBs on testicular function are not mentioned in the provided paper. | |
Open access•Journal Article 3 Citations | The paper discusses the effects of PCBs on different types of cells in the testis, including testicular germ cells, Leydig cells, and Sertoli cells. However, it does not provide specific information on the effects of PCBs on overall testicular function. |
11 Citations | The effects of PCBs on testicular function include inhibiting testicular steroidogenesis by downregulating P450(17alpha) and P450(scc) proteins. |
| The effects of PCBs on testicular function include testicular injury, poor sperm quality, oxidative stress, inflammation, DNA fragmentation, and activation of apoptosis. | |
| The effects of PCBs on testicular function include decreased sperm production, decreased sperm counts, and decreased testosterone levels in adult male rats. |
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