What are the impacts of treatment with mesenchymal stem cells on abortion in mice?
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Treatment with mesenchymal stem cells (MSCs) in mice has been shown to have a positive impact on abortion rates. MSCs can modulate immune responses and create an immune-privileged microenvironment at the fetomaternal interface, protecting the fetus from detrimental immune responses . MSC therapy can decrease the infiltration of CD49b+ natural killer (NK) cells to the fetomaternal interface and modulate the cytokine profile of NK cells from inflammatory to tolerogenic, improving the tolerogenic microenvironment and pregnancy maintenance . MSC therapy also reduces resorption rates in mice by modulating immune responses in the fetomaternal interface and protecting the fetus . Adoptive transfer of MSCs prevents fetal loss by inhibiting CD4+ T cell proliferation and promoting the switch of decidual macrophages to an anti-inflammatory phenotype, mediated by the production of tumor necrosis factor-stimulated gene-6 (TSG-6) . These findings suggest that MSC therapy has the potential to be used in the treatment of recurrent miscarriages .
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108 Citations | The treatment with mesenchymal stem cells (MSCs) reduced fetal loss in mice and decreased T-cell-mediated inflammatory responses in abortion models. |
18 Citations | Treatment with mesenchymal stem cells significantly reduces the abortion rate in mice and modulates immune responses in the fetomaternal interface. |
14 Citations | The impacts of treatment with mesenchymal stem cells on abortion in mice were evaluated in the study. The results showed that mesenchymal stem cells decreased the frequency of CD49b+ natural killer cells and modulated their cytokine profile, potentially improving the tolerogenic microenvironment and benefiting pregnancy maintenance. |
3 Citations | Treatment with mesenchymal stem cells in abortion-prone mice reduced the abortion rate and induced expansion of regulatory T cells, which may contribute to the protection of the fetus. |
| The impacts of treatment with mesenchymal stem cells on abortion in mice are improved pregnancy outcomes and decreased embryo resorption rate. |
Related Questions
What is the therapeutic potential of mesenchymal stem cells ?5 answersMesenchymal stem cells (MSCs) exhibit significant therapeutic potential in various medical conditions. They possess unique properties such as self-renewal, differentiation into different cell types, and modulation of immune cells. In the context of COVID-19, MSCs have shown promise in improving immune system dysregulation through their anti-inflammatory and immunomodulatory effects, leading to reduced levels of inflammatory markers like C-reactive protein and IL-6. Furthermore, MSCs have been studied for their effectiveness in treating polycystic ovary syndrome (PCOS), where different types of MSCs have demonstrated the ability to restore ovarian structure, enhance oocyte numbers, and alleviate inflammation in granulosa cells. Overall, MSCs' multipotent nature, immunomodulatory capabilities, and regenerative properties make them a valuable tool in developing novel therapies for a range of diseases.
Publications about toxic effect of MSC on reproductive functions ?5 answersStudies have explored the impact of mesenchymal stem cells (MSCs) on reproductive functions. Research has shown that human umbilical cord MSCs did not exhibit toxicity on fertility or teratogenic effects in rats, with specific dosage levels identified. Additionally, bone marrow MSC-derived exosomes were found to counteract cyclophosphamide-induced testicular spermatogenic dysfunction in rats through signaling pathways. Furthermore, human MSC secretome was observed to enhance granulosa cell proliferation and function, potentially offering a novel treatment for primary ovarian insufficiency by restoring ovarian function. Moreover, bone marrow MSC-derived factors were shown to protect against gonadotropic toxicity induced by busulfan in mice, reducing apoptotic spermatogenic cells and enhancing intercellular adhesion molecule expressions. These findings collectively contribute to understanding the toxic effects and therapeutic potential of MSCs on reproductive functions.
What are the impacts of treatment with mesenchymal stem cells on abortion?5 answersTreatment with mesenchymal stem cells (MSCs) has been shown to have positive impacts on abortion. MSCs can modulate immune responses and create an immune-privileged microenvironment at the fetomaternal interface, which helps protect the fetus. MSCs therapy can decrease the infiltration of CD49b+ natural killer (NK) cells to the fetomaternal interface and modulate the cytokine profile of NK cells from inflammatory to tolerogenic, thereby improving the tolerogenic microenvironment and benefiting pregnancy maintenance. MSCs-derived exosomes can modulate T cells' function and macrophages' activities in the maternal-fetal interface, resulting in a decreased embryo resorption rate and providing a therapeutic potential to treat recurrent pregnancy loss (RPL). MSCs can prevent fetal loss by inhibiting CD4+ T cell proliferation and promoting the decidual macrophage switch to M2 in a TSG-6-dependent manner, thereby inducing immune tolerance. MSCs therapy can also modulate immune responses in the fetomaternal interface, protect the fetus, and reduce the abortion rate by upregulating TGF-β and IL-10 and downregulating IFN-γ and TNF-α gene expression in deciduas.
What is the impact of abortion on women's health?4 answersAbortion has various impacts on women's health. Self-administered use of over the counter pills for medical termination of pregnancy without supervision can lead to complications and a higher failure rate compared to supervised pill intake. Legal access to abortion has resulted in a decline in maternal morbidity, particularly morbidity due to haemorrhage early in pregnancy. Abortion restrictions and bans have been found to contribute to higher rates of frequent mental distress in women. Early loss of pregnancy and missed abortion can have a significant impact on women's mental health, leading to emotional distress and grief. The loss of reproductive rights and restrictions on legal abortions put women at risk of severe physical and mental health consequences, including illegal abortions with associated risks and limitations on life-saving abortions in medical emergencies.
What are the positive effects of abortion?5 answersAbortion has been found to have several positive effects. One study found that the legalization of abortion led to a decline in gonorrhea incidence among 15-19-year-olds, particularly among Black women. Another study showed that most women who decide to terminate their pregnancy experience relief and a decrease in signs of anxiety and depression after abortion. Additionally, research has shown that women who have abortions do not fare worse psychologically in the long term compared to women who give birth, although around 30% may still experience emotional problems after a month. Furthermore, abortion has been found to enhance the survivability of newborns and improve the distribution of births among high-risk groups, leading to better infant health outcomes. Overall, the public health effect of legal abortions has been a reduction in pregnancy-related mortality.
What is the optimal dosage of human umbilical cord mesenchymal stem cells in mice?5 answersThe optimal dosage of human umbilical cord mesenchymal stem cells (HUC-MSCs) in mice varies depending on the specific condition being treated. In the context of lupus mice, multiple infusions of HUC-MSCs at Weeks 12 and 16 resulted in a significantly higher number of primordial follicles compared to infusions at only Week 12. In the case of food allergy in mice, the administration of HUC-MSCs intraperitoneally combined with oral gavage of the culture medium showed significant alleviation of symptoms. For emphysema in mice, the administration of HUC-MSCs at 107 cells/kg body weight via intravenous administration was effective in reducing emphysema severity. In the context of acute lung injury (ALI) in mice, intratracheal administration of HUC-MSCs improved survival and attenuated lung inflammation. The optimal dosage for treating psoriasis-like skin inflammation in mice with HUC-MSCs was not specified in the available abstracts.