What are the negative effects of cannabis use?5 answersCannabis use is associated with various negative effects on mental health, cognition, behavior, and physical health. These effects include an increased risk of developing cannabis use disorder, cognitive impairment, structural brain differences, subtle cognitive deficits, psychosis, schizophrenia, mood disorders, anxiety, depression, and permanent brain deficits. Additionally, cannabis use may lead to respiratory and pulmonary complications, immune dysfunction, and an increased risk of acquiring or transmitting viral infections like HIV, HCV, and others. The negative outcomes are influenced by factors such as frequency of use, THC content, age of onset, and cumulative exposure, highlighting the importance of understanding vulnerability to these adverse effects for prevention and treatment purposes.
What is the complication rate of colon ESD?4 answersThe complication rate of colon ESD varies across studies. One study reported a slightly higher complication rate in the right colon compared to the left colon, although the difference was not statistically significant. Another study found that ESD in the right colon was associated with a higher rate of complications, including perforation, compared to other locations in the colon. However, a different study reported a low overall complication rate for ESD in the right colon, with postoperative complications occurring in only 3.8% of cases. Additionally, a study analyzing the technical success, complications, and clinical outcomes of ECD (endoscopic trans-anal colonic decompression) found a low periprocedural complication rate of 3%. While complications such as bleeding, perforation, and coagulation syndrome have been reported in colorectal ESD, bowel obstruction after ESD is considered rare.
What are the worst side effects of kratom?4 answersThe worst side effects of kratom include respiratory failure requiring mechanical ventilation, negative experiences associated with anger, fear, disgust, and sadness, acute liver injury and jaundiceand rhabdomyolysis, which can lead to multiorgan dysfunction including acute kidney injury, liver dysfunction, and cardiomyopathy. Other reported side effects include seizures, hallucinations, cognitive and behavioral impairment, hypertension, tachycardia, agitation, dry mouth, and respiratory depression. Additionally, kratom has been associated with complications such as respiratory depression, cardiopulmonary arrest, torsade de pointes, and sudden cardiac death. It is important for healthcare professionals to be aware of these potential adverse effects and to report any adverse reactions to regulatory authorities.
What are the side effects of probiotics?5 answersProbiotics can have several side effects. The most common adverse effects include gastrointestinal disorders such as diarrhea, nausea, flatulence, dyspepsia, and abdominal pain. Other side effects can include respiratory tract infections, abscesses, allergic reactions, and severe medical conditions such as sepsis, fungemia, and endocarditis. Probiotics also have the potential for gene transfer, which can lead to antibiotic resistance. Additionally, there are theoretical concerns about the risk of harmful metabolic activities, adjuvant side effects, and immunomodulation. It is important to note that the safety of probiotics depends on factors such as the vulnerability of the consumer, the dose and duration of use, and the frequency of consumption. Further research is needed to better understand the potential risks and benefits of probiotics.
What are the common side effects of cabotegravir?5 answersCabotegravir is a long-acting injectable drug used for pre-exposure prophylaxis (PrEP) in HIV prevention. The common side effects of cabotegravir include the development of integrase-inhibitor drug resistance, which can undermine treatment programs relying on other drugs such as dolutegravir. However, there is no information available on the specific side effects of cabotegravir in the abstracts provided.
What are the most significant adverse effects of cyclophosphamide?5 answersThe most significant adverse effects of cyclophosphamide include myelosuppression, reproductive health impairment, ovarian damage, and gastrointestinal side effects. Myelosuppression, characterized by decreased white blood cell levels, can be mitigated by Angelica gigas Nakai (AGN) roots. Multiple exposures to cyclophosphamide can lead to irreversible follicle loss, oocyte impairments, and decreased anti-Mullerian hormone levels, affecting reproductive health. Cyclophosphamide can also induce adverse effects on placental development, resulting in fetal resorption, external malformations, and placental abnormalities. Additionally, cyclophosphamide has been associated with severe small bowel enteritis and pan-colitis, which can be fatal.