What are the most common resistance mechanisms detected through whole-genome sequencing (WGS) in bacterial populations?
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Through whole-genome sequencing (WGS), common resistance mechanisms detected in bacterial populations include the presence of genes like cfr, optrA, and poxtA, mutations in 23S rRNA, and ribosomal proteins (L3, L4, L22). Additionally, the resistome encompasses a variety of genes facilitating antibiotic resistance, such as linezolid methyltransferases (cfr), aminoglycoside ribosomal methylases (armA, rtmB), and efflux pumps conferring fluoroquinolone resistance (qepA). WGS aids in identifying acquired antibiotic resistance genes and mutations, allowing for accurate prediction of resistance patterns. Furthermore, WGS has been instrumental in characterizing the resistome in clinical bacterial isolates, highlighting the importance of standardized procedures and databases for reliable antimicrobial resistance genotyping. This multidisciplinary approach has also been used to monitor genetic patterns of antimicrobial resistance in livestock-wildlife interfaces, revealing resistance to critical antibiotics like linezolid.
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| The most common resistance mechanisms detected through WGS in bacterial populations include plasmid-borne AMR genes, enhanced sensitivity with hybrid assemblies of short and long reads, and challenges in distinguishing mobile from chromosomal genes. | |
1 Citations | Resistance mechanisms detected through WGS in bacterial populations include phenotypic and genotypic resistance to tetracycline, linezolid, carbapenems, and virulence genes related to biofilm regulation and Shiga toxins. |
| Common resistance mechanisms detected through WGS include 57 acquired resistance genes and 18 mutations for various antibiotics, aiding in predicting phenotypic resistance accurately in E. coli isolates. | |
1 Citations | Common resistance mechanisms detected through WGS in bacterial populations include cfr, armA, rtmB for ribosomal methyltransferases, qepA for efflux pumps, and biofilm resistance genes. |
| The most common resistance mechanisms detected through WGS in Staphylococcus haemolyticus populations are the cfr gene, G2603T mutation in 23S rRNA, and R138V mutation in L3 ribosomal protein. |
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