What endpoints for assessing pain do studies treating pain due to osteoarthritis of the knee use?
Best insight from top research papers
Studies treating pain due to osteoarthritis of the knee commonly use endpoints such as total knee replacement (TKR) and composite endpoints that combine TKR with conservative thresholds of patient-reported outcomes (PROs) of pain and function . These endpoints are crucial in evaluating the effectiveness of therapies for knee osteoarthritis, as they directly capture clinical benefit and provide a reliable measure of treatment success. By utilizing these endpoints, researchers can assess the impact of interventions on pain relief and functional improvement in patients with knee osteoarthritis, ultimately aiming to enhance their quality of life and mobility. Additionally, the use of composite endpoints has been shown to reduce sample sizes required for studies, making the evaluation process more feasible and efficient .
Answers from top 4 papers
More filters
| Papers (4) | Insight |
|---|---|
| Studies treating knee osteoarthritis pain use VAS, IKDC, and WOMAC scales to assess pain and function outcomes, as highlighted in the research comparing corticosteroids and PRP injections. | |
9 Citations | Studies treating pain due to knee osteoarthritis use endpoints like total knee replacement (TKR) and composite endpoints combining TKR with thresholds for patient-reported pain and function. |
| Studies treating knee osteoarthritis pain use clinical symptoms, pain assessment tools, and imaging as endpoints to assess pain. Individualized pain management plans may enhance patient outcomes and data collection. | |
10 Citations | Studies treating pain due to knee osteoarthritis use endpoints like total knee replacement (TKR) and composite endpoints combining TKR with thresholds for pain and function in clinical trials. |
Related Questions
What kind of instrument did opioid trials use to assess satisfaction with treatment result?4 answersOpioid trials utilized various instruments to assess satisfaction with treatment results. One study focused on patient satisfaction in individuals with opioid use disorder (OUD) and used the 8-item version of the Client Satisfaction Questionnaire (CSQ). Another study evaluated the psychometric properties of the Persian version of the Treatment Satisfaction Questionnaire for Medication (TSQM) version II in opioid-dependent patients, which contained 11 items in four subscales. Additionally, a different trial compared patient satisfaction between depot buprenorphine and sublingual buprenorphine using the Treatment Satisfaction Questionnaire for Medication (TSQM) version 1.4, where higher scores indicated greater satisfaction. These studies highlight the importance of utilizing standardized tools like the CSQ and TSQM to comprehensively assess patient satisfaction with treatment outcomes in opioid trials.
What are the most commonly used endpoints for assessing pain in individuals with knee osteoarthritis?4 answersThe most commonly used endpoints for assessing pain in individuals with knee osteoarthritis include the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain, WOMAC Physical Function, WOMAC Pain/Function composite, and weekly average pain. Additionally, patient acceptable symptom state (PASS) composite responders, minimal clinically important improvement (MCII) composite responders, Outcome Measures in Rheumatology-Osteoarthritis Research Society International (OMERACT-OARSI) responders, and sustained weekly average pain responders are also utilized. Furthermore, pain sensitivity is an important aspect to consider in assessing pain in knee osteoarthritis patients, with studies showing that individuals with knee osteoarthritis have higher levels of pain sensitivity compared to those without pain, but lower levels than individuals with chronic back pain.
What is the percentage of knee osteoarthritis patients with chronic pain?4 answersApproximately 30% of individuals with chronic knee pain meet the criteria for chronic widespread pain (CWP). Chronic pain is a common issue in osteoarthritis (OA) patients, affecting a significant portion of the population. In a study focusing on OA patients in France, the prevalence of chronic pain in patients receiving opioid agonist treatments (OAT) was estimated at 33.2%. Moreover, chronic pain is a significant concern post-total hip and knee arthroplasties (THA/TKA), with 7-23% and 10-34% of patients experiencing chronic pain, respectively. These findings highlight the substantial impact of chronic pain on OA patients, emphasizing the importance of effective pain management strategies to improve the quality of life and overall outcomes for individuals with knee osteoarthritis.
What are latest research on endpoints to measure parkinson progression?4 answersRecent research on endpoints to measure Parkinson's disease (PD) progression has focused on the need for clinically meaningful, patient-centric, objective, and quantitative measures that can accurately represent longer-term outcomes. Currently, there is a lack of robust disease progression biomarkers in PD, hindering the measurement of treatment effectiveness and the development of disease-modifying therapies. Efforts have been made to identify and validate suitable digital biomarkers, such as digital measures of signs and symptoms, imaging biomarkers, and biospecimen biomarkers. However, the implementation of these biomarkers as tools for quantifying changes in disease status or severity remains elusive. The use of surrogate biomarkers for disease progression in clinical trials may help differentiate symptomatic effects from true disease-modifying effects, but there is insufficient evidence to recommend the use of any biomarker for PD clinical trials at present. There is an urgent need for biomarkers that can accurately reflect advancing neurodegeneration and resulting clinical disability in PD, and that can be used in shorter-term clinical trials testing potential disease-modifying agents.
What is the average level of koos-12 scoring in patients with knee osteoarthritis?5 answersThe average level of KOOS-12 scoring in patients with knee osteoarthritis is not explicitly mentioned in the abstracts provided. However, the abstracts do provide information on the validity, reliability, and responsiveness of the KOOS-12 questionnaire in patients with knee osteoarthritis. The Spanish version of the KOOS-12 demonstrated high internal consistency and reproducibility, with a high correlation with the Spanish Oxford Knee Score (S-OKS). The Bulgarian version of the KOOS questionnaire was found to be valid and reliable for use in Bulgarian patients with osteoarthritis of the knee. The Spanish version of the KOOS-12 was also found to be a valid, reliable, and responsive questionnaire for measuring patients' opinions about their knee and associated problems in Mexican subjects with knee osteoarthritis. The Hindi version of the KOOS was found to be a valid, reliable, and responsive measure for evaluating osteoarthritis of the knee.
What are the different methods of assessing pain sensitization?2 answersPain sensitization can be assessed using various methods. One approach is the use of self-report measures, which aim to characterize multiple aspects of the pain experience such as chronicity, severity, quality, locations, affective impact, and associated factors. Another method involves the administration of domain-specific measures that evaluate different dimensions of pain, such as pain severity, sensory qualities, pain beliefs, coping strategies, and functional impact. Additionally, there are multidimensional scales available, such as the McGill Pain Questionnaire and the Multidimensional Pain Inventory, which allow for the assessment and management of the diverse components of pain. In specific clinical situations, thermal stimulation and measurement of the latent period of pain sensation can be used to determine pain sensitivity. Overall, the selection of the most appropriate pain assessment tool depends on the specific context, whether it is everyday practice or research.