What is the best method and administration regime for TXA in patients undergoing arthoplasty?
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In patients undergoing arthroplasty, the most effective administration of Tranexamic Acid (TXA) involves intravenous (IV) dosing. Studies have shown that IV administration of TXA, either as a single dose or in two doses, significantly reduces total blood loss and transfusion rates . Additionally, combining IV administration with local infiltration of TXA has been found to be more effective in reducing perioperative blood loss compared to single IV dosing. Topical administration of TXA is less effective and is recommended only when systemic administration is contraindicated. Overall, the consensus leans towards IV administration of TXA, either as a single dose or in two doses, for optimal efficacy in reducing blood loss and transfusion requirements in patients undergoing arthroplasty.
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| Papers (5) | Insight |
|---|---|
| Intravenous combined with local infiltration of TXA is more effective in reducing perioperative blood loss in unilateral total hip arthroplasty compared to single intravenous administration. | |
| The review suggests various TXA administration methods like IV, intra-articular, or a combination, but the best method for reducing blood loss in arthroplasty remains inconclusive in the literature. | |
1 Citations | In primary total knee arthroplasty, the most effective TXA administration is intravenous in two doses or a combined regimen, showing lower blood loss compared to topical administration. |
| The study did not specify the ideal method or administration regime for TXA in patients undergoing arthroplasty. Different dosages and routes were used without a clear recommendation. | |
| Topical TXA is safer with reduced complications, while IV TXA is superior in total knee arthroplasty. Both routes effectively reduce bleeding and transfusion requirements in arthroplasty patients. |
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