What is the concentration range of metabolies?
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The concentration range of metabolites can be efficiently computed in mass-action metabolic networks using network properties. This approach does not require knowledge of kinetic parameters and can be applied to genome-scale metabolic models of different organisms . Additionally, a high-resolution magic angle spinning nuclear magnetic resonance technique has been developed to obtain absolute metabolite concentrations of solutions, with a demonstrated accuracy of within 7% . Gas chromatography coupled to atmospheric pressure chemical ionization mass spectrometry (GC-APCI-MS) has an average linear range of 2.39 orders of magnitude for metabolite analysis, which can be extended by more than 1 order of magnitude using a computational tool . Proton magnetic resonance spectroscopy combined with T1-weighted high-resolution imaging allows for the extraction of absolute metabolic concentrations in the brain, with corrections for tissue distributions and individual cortical spinal fluid fraction .
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| Papers (5) | Insight |
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| The paper discusses a computational approach to infer concentration ranges from genome-scale metabolic models, but it does not explicitly provide the concentration ranges of metabolites. | |
7 Citations | The paper discusses network properties that can be used to compute the concentration ranges of metabolites in mass-action metabolic networks. The derived ranges are in agreement with simulations and can be used for predictions in various applications. However, the specific concentration ranges of metabolites are not mentioned in the paper. |
2 Citations | The concentration range of metabolites is not mentioned in the paper. The paper discusses a new technique for obtaining absolute metabolite concentrations but does not provide specific information about the concentration range. |
01 Jan 2009 6 Citations | The concentration range of metabolites is not mentioned in the paper. |
18 Citations | The concentration range of metabolites in the paper is not explicitly mentioned. |
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