What is the effect of probiotics on osteoarthritis?
Best insight from top research papers
Probiotics have shown promising effects on osteoarthritis (OA) by modulating inflammation, pain, gut barrier function, and fecal metabolomics. Studies have demonstrated that probiotic supplementation can improve symptoms in OA patients, reduce inflammation, and enhance bone metabolism . Additionally, prebiotics have been found to protect against post-traumatic osteoarthritis by reducing cartilage degeneration, osteophyte formation, and inflammation, while also enhancing gut barrier function . Furthermore, the use of autoprobiotics in spondyloarthritis patients has shown effectiveness in reducing pain intensity, dyspeptic symptoms, and restoring microbiota balance . In animal models, probiotics like Lactobacillus acidophilus have demonstrated the ability to reduce inflammatory knee joint pain, prevent OA progression, and modulate the fecal microbiome, suggesting a potential as a disease-modifying therapeutic agent for OA .
Answers from top 4 papers
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| Papers (4) | Insight |
|---|---|
| Prebiotics, not probiotics, alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics, delaying disease progression. | |
| The paper provides evidence that the probiotic Lactobacillus acidophilus (LA) has beneficial effects on osteoarthritis (OA), including reducing joint pain, preventing further OA progression, and altering the gut microbiota. | |
| The provided paper is about the use of autoprobiotics in the complex therapy of axial spondyloarthritis. It does not mention the effect of probiotics on osteoarthritis. | |
| Probiotic supplementation in patients with osteoarthritis (OA) improved WOMAC and VAS scores and reduced hs-CRP levels, suggesting its potential as a therapeutic agent for OA management. |
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