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What is the emax? 

Marginal likelihood
Expectation–maximization algorithm
Covariance matrix
Vilanterol
Salmeterol
Best insight from top research papers

The EMAX (Early MAXimisation of bronchodilation for improving COPD stability) trial is a significant study focusing on the comparison of dual- versus mono-bronchodilation therapies in patients with chronic obstructive pulmonary disease (COPD) who are at low exacerbation risk and not receiving inhaled corticosteroids. This 24-week trial evaluated the efficacy of umeclidinium/vilanterol, umeclidinium, and salmeterol in improving lung function, symptoms, health status, exacerbations, and overall treatment outcomes. Results showed that umeclidinium/vilanterol consistently provided superior improvements in lung function, symptoms, and reduced the risk of deterioration or treatment failure compared to mono-bronchodilator therapies, regardless of smoking status. The trial highlighted the potential benefits of early use of dual bronchodilators in optimizing therapy for symptomatic COPD patients, emphasizing the importance of considering dual-bronchodilator therapy in this patient group .

Answers from top 4 papers

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Papers (4)Insight
Open access•Journal Article•DOI
Salbutamol use in relation to maintenance bronchodilator efficacy in COPD: a prospective subgroup analysis of the EMAX trial.
François Maltais, Ian Naya, Claus Vogelmeier, Isabelle Boucot, Paul W. Jones, Leif Bjermer, Lee Tombs, Chris Compton, David A. Lipson, Edward Kerwin 
22 Oct 2020-Respiratory Research
7 Citations
EMAX refers to the Early MAXimisation of bronchodilation for improving COPD stability trial, focusing on bronchodilator efficacy in COPD patients using different maintenance treatments.
Book Chapter•DOI
The EM Algorithm
Shu-Kay Ng, Thriyambakam Krishnan, Geoffrey J. McLachlan 
01 Jan 2012-Research Papers in Economics
178 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial
François Maltais, Leif Bjermer, Edward Kerwin, Paul W. Jones, Michael L. Watkins, Lee Tombs, Ian Naya, Isabelle Boucot, David A. Lipson, Chris Compton, Mitra Vahdati-Bolouri, Claus Vogelmeier 
30 Oct 2019-Respiratory Research
76 Citations
EMAX refers to the Early MAXimisation of bronchodilation for improving COPD stability trial, comparing umeclidinium/vilanterol with monotherapies in COPD patients not on inhaled corticosteroids.
Open access•Journal Article•DOI
Efficacy and Safety of Umeclidinium/Vilanterol in Current and Former Smokers with COPD: A Prespecified Analysis of The EMAX Trial.
Leif Bjermer, Isabelle Boucot, Claus Vogelmeier, François Maltais, Paul W. Jones, Lee Tombs, Chris Compton, David A. Lipson, Edward Kerwin 
04 Aug 2021-Advances in Therapy
3 Citations
The EMAX trial evaluated the efficacy and safety of umeclidinium/vilanterol in current and former smokers with COPD, showing improved lung function and symptom relief compared to single bronchodilators.

Related Questions

What are ARMAX models?4 answersARMAX models, short for Auto-Regressive Moving-Average with eXogenous input models, are utilized in various fields for system representation. These models incorporate exogenous input variables, allowing for a more comprehensive analysis of system dynamics. ARMAX models are particularly beneficial in scenarios where measurement uncertainties on the output need to be considered, enhancing the model's fidelity. By employing ARMAX models, researchers have successfully developed dynamic models for cooling systems integrated with thermoelectric cooling and for predicting glucose-insulin interactions in diabetes patients. These models have proven effective in capturing complex relationships within systems, offering valuable insights for system control and prediction tasks.
What is emdr?5 answersEye Movement Desensitization and Reprocessing (EMDR) is a therapy used to treat people with post-traumatic stress disorders (PTSD). It involves the use of bilateral stimulation, such as eye movements or other repetitive movements, to aid in the reprocessing of traumatic memories. EMDR is considered a transdiagnostic intervention that can be applied across various mental health conditions. It addresses key factors such as adverse experiences, maladaptive cognitions, and emotional dysregulation that are common across different psychopathologies. EMDR has been found to be effective in reducing symptomatology, desensitizing traumatic memories, and providing cognitive restructuring. It is a client-centered approach that can be used within a comprehensive treatment plan. EMDR has been shown to be safe and effective in the treatment of PTSD and other trauma- and stress-based conditions. Additionally, there is emerging evidence suggesting the potential use of EMDR in managing other mental and physical health conditions such as anxiety disorders, obsessive-compulsive disorder, major depressive disorder, and chronic pain.
What is emo?4 answersEMO, or Episodic Memory Optimization, is a meta-learning approach that addresses the challenge of few-shot learning by retaining the gradient history of past tasks in external memory. Inspired by the human ability to recall past learning experiences, EMO enables parameter updates in the right direction even with limited informative gradients from a small number of examples. The algorithm is proven to converge for smooth, strongly convex objectives and can be seamlessly embedded into existing optimization-based meta-learning methods. EMO is generic, flexible, and model-agnostic, resulting in accelerated convergence and improved performance on few-shot classification benchmarks.
What is emdr?1 answersEye Movement Desensitization and Reprocessing (EMDR) therapy is an innovative and rapid technique for reducing trauma and anxiety disorders. It is an integrative eight-phase approach that emphasizes the role of physiologically stored memory networks and the brain's information processing system in the treatment of pathology. EMDR therapy is guided by the Adaptive Information Processing (AIP) model, which suggests that mental health problems are the result of inadequately processed memories of adverse life experiences. These memories of disturbing experiences are dysfunctionally stored, encoded with the original emotions, beliefs, and physical sensations, leading to presenting symptoms. EMDR therapy has been successfully used with various populations, including victims of traumatic events such as bombings, natural disasters, war veterans, and survivors of abuse. It offers a multimodal approach that can be particularly effective with clients who may not respond well to verbal psychotherapy due to minimal language skills.
What is etoP?4 answersThe ETOP (Education and Training in Optics and Photonics) meeting is the oldest international conference dedicated to optics and photonics education. It has been held biennially since 1988 and covers education at all levels, from K-12 to vocational education. The conference has been organized by various groups and held at different locations worldwide. The history, locations, and participants of the meetings have been comprehensively surveyed, providing quantitative metrics for the conference. This data can inform decisions for future ETOP meetings and guide the collection of additional data.
What is ehalth?5 answersHealth refers to the overall well-being and functioning of an individual's body and mind. It encompasses physical, mental, and social aspects of a person's life. Maintaining good health involves adopting healthy lifestyle habits, such as regular exercise, balanced nutrition, adequate sleep, and stress management. It also includes seeking medical care when needed and staying up-to-date with preventive measures like vaccinations. Good health is essential for a high quality of life and can contribute to longevity and productivity.

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