What is the evidence for chronic pain due to vitamin D deficiency?
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Vitamin D deficiency has been associated with chronic pain conditions such as chronic widespread musculoskeletal pain (CWP) and chronic low back pain (cLBP) . Studies have shown that individuals with vitamin D deficiency may experience greater pain severity . Randomized controlled trials (RCTs) have demonstrated that vitamin D supplementation can lead to pain reduction in patients with chronic musculoskeletal pain . However, the efficacy of vitamin D supplementation in relieving pain in patients with CWP remains inconclusive, with some meta-analyses suggesting no significant benefit . Mendelian randomization analyses have also shown that genetically-predicted levels of vitamin D are not associated with fibromyalgia, clinical fatigue, chronic widespread pain, or probable lifetime major depression . Overall, while there is evidence linking vitamin D deficiency to chronic pain conditions, the effectiveness of vitamin D supplementation in relieving pain may vary depending on the specific condition and individual characteristics.
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| The paper provides evidence that Vitamin D deficiency may be linked to greater pain severity in individuals with chronic low back pain, especially for those who identify as Non-Hispanic Black. | |
| The paper provides evidence that there is a correlation between chronic musculoskeletal pain and vitamin D deficiency. Supplementation with vitamin D can reduce musculoskeletal pain in vitamin D-deficient individuals. | |
| The paper discusses a randomized controlled trial (RCT) conducted in France to assess the efficacy of vitamin D supplementation in relieving pain in young adult patients with chronic widespread musculoskeletal pain and vitamin D deficiency. The study found no evidence that vitamin D supplementation alone was better than placebo in relieving pain. | |
| The paper provides evidence that vitamin D deficiency may be linked to greater pain severity in individuals with chronic low back pain, especially for those who identify as Non-Hispanic Black. |
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