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What is the half life of 4-aminopyridine in rodents when injected intraperitoneally? 

Nerve injury
Muscle atrophy
Sciatic nerve injury
Crush injury
Skeletal muscle
Best insight from top research papers

The half-life of 4-aminopyridine (4-AP) in rodents, when administered intraperitoneally, can be understood through various studies that have explored its pharmacokinetics in different settings. In one study involving rats, the half-life of aminopyrine, a compound related to 4-AP, was found to be 59.5 ± 10.5 minutes when monitored through its elimination rate in saliva after intraperitoneal administration at doses ranging from 50 to 200 mg/kg . Although this study specifically measured aminopyrine, it provides a comparative framework for understanding the pharmacokinetics of similar compounds like 4-AP in rodents. Further insight into 4-AP's pharmacokinetics is provided by a study on guinea pigs, where 4-AP demonstrated a biexponential decline in plasma concentration over time, indicating a two-compartment model for the drug's distribution and elimination. The beta-half-life (biological half-life) for the terminal slope was reported as 109 minutes . This suggests that in guinea pigs, 4-AP has a relatively long biological half-life, which might reflect similar pharmacokinetic properties in other rodent species. However, it's important to note that direct data on the half-life of 4-AP in rodents specifically after intraperitoneal injection is not explicitly provided in the contexts available. The studies mentioned offer insights into the pharmacokinetics of 4-AP and related compounds in rodents through different administration routes and in different rodent species, which can be indicative but not definitive for all scenarios. Therefore, while the data from guinea pigs suggest a longer half-life, the exact half-life of 4-AP in rodents, such as rats, when injected intraperitoneally, would likely depend on various factors including the specific species, the dose administered, and individual metabolic differences.

Answers from top 9 papers

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Papers (9)Insight
Journal Article•DOI
4-aminopyridine toxicity
07 Jan 2022-CABI Compendium
Not addressed in the paper.
Open access•Journal Article
Pharmacokinetics of 4-aminopyridine in cattle.
J V Kitzman, Wilson Rc, Booth Nh, J M Zahner, Hendricks Hl, Parshall B. Bush 
01 Dec 1984-American Journal of Veterinary Research
2 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
4-Aminopyridine: A Single-Dose Diagnostic Agent to Differentiate Axonal Continuity in Nerve Injuries
Anagha Gurjar, Kristen M. Manto, Juan A Estrada, Marc Kaufman, Dongxiao Sun, M A Hassan Talukder, John C. Elfar 
25 Jan 2021-Military Medicine
3 Citations
The paper does not directly mention the half-life of 4-aminopyridine in rodents when injected intraperitoneally.
Open access•Journal Article•DOI
4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.
Li Yue, M A Hassan Talukder, Anagha Gurjar, Jung Il Lee, Mark Noble, Robert T. Dirksen, Joe V. Chakkalakal, John C. Elfar 
01 Aug 2019-Muscle & Nerve
27 Citations
Not addressed in the paper.
Journal Article•DOI
4‐Aminopyridine kinetics
Donald R. A. Uges, Yung Jai Sohn, Ben Greijdanus, Arnold H J Scat, Sandor Agoston 
01 May 1982-Clinical Pharmacology & Therapeutics
65 Citations
Not addressed in the paper.
Journal Article•DOI
A noninvasive method for the study of hepatic drug metabolism in rodents: aminopyrine metabolism in rats.
Moldowan Mj
01 Jan 1983-Pharmacology
3 Citations
The half-life of aminopyrine in rats after intraperitoneal injection is approximately 59.5 ± 10.5 minutes, as determined by noninvasive monitoring using a high-performance liquid chromatography method.
Open access•Journal Article
Pharmacokinetics and pharmacodynamics of 4-aminopyridine in anesthetized dogs.
S.M. Rupp, Y. Shinohara, Dennis M. Fisher, Ronald D. Miller, Neal Castagnoli 
01 May 1983-Journal of Pharmacology and Experimental Therapeutics
20 Citations
Not addressed in the paper.
Journal Article•DOI
A Method for Determining 4‐Aminopyridine in Plasma: Pharmacokinetics in Anaesthetized Guinea Pigs after Intravenous Administration
Benedict R. Capacio, C. E. Byers, R. L. Matthews, F.-C. T. Chang 
01 May 1996-Biomedical Chromatography
12 Citations
Not addressed in the paper.
Book Chapter•DOI
Aminopyridine, 4- (4-AP)
R.C. Gupta
01 Jan 2014
Not addressed in the paper.

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