What is the molecular mechanism behind BPC157's neuroprotective effects?
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BPC157 exerts neuroprotective effects through various mechanisms. It modulates the regional synthesis of 5-HT in the brain , promotes angiogenesis by upregulating VEGFR2 expression and activating the VEGFR2-Akt-eNOS signaling pathway , and regulates cytosolic and mitochondrial Ca2+ dynamics to prevent excitotoxicity and neuronal cell death . Additionally, BPC157 can rescue cancer cachexia by targeting anorexia, hypoanabolism, and hypercatabolism, offering a potential therapeutic approach for this condition . Furthermore, BPC157, when modified by CD157, enhances the transfer of extracellular mitochondrial particles from BMSCs to injured neurons, promoting axon regeneration and reducing cell apoptosis in spinal cord injury models . These multifaceted actions collectively contribute to BPC157's neuroprotective properties.
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52 Citations | CGP37157 protects neurons by inhibiting mitochondrial Na+/Ca2+ exchanger, reducing Ca2+ overload via voltage-gated Ca2+ channel blockage, thus preventing excitotoxicity-induced mitochondrial dysfunction and cell death. |
| CD157 upregulation in BMSCs enhances extracellular mitochondrial transfer to neurons, reducing apoptosis and promoting functional recovery after spinal cord injury, suggesting a novel neuroprotective mechanism involving mitochondrial transfer. | |
45 Citations | BPC157's neuroprotective effects in cancer cachexia may involve central nervous system modulation, anorexia alleviation, and anti-inflammatory properties, potentially rescuing patients from muscle wasting and weight loss. |
30 Citations | The molecular mechanism behind BPC157's neuroprotective effects involves increasing survival of enteric neurons and promoting proliferation of enteric glial cells, aiding in healing damaged structures in the gastrointestinal tract. |
58 Citations | Not addressed in the paper. |
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