What is the potential challenge for using Zr with HA as bone implant?
Best insight from top research papers
One potential challenge for using Zr with HA as a bone implant is the difficulty in achieving a uniform coating on the substrate. This challenge arises due to the tendency of coating layers on Ti and Ti alloy substrates, which include Zr, to peel off after implantation. Additionally, the sintering ability of HA-added Ti-Nb-Zr alloys was found to decrease, impacting the overall biocompatibility and physical properties of the composite. While Zr implants have shown comparable bone-to-implant contact to Ti implants in animal studies, the deposition of HA coatings on both Zr and Ti implants did not significantly enhance their bone integration. These findings highlight the importance of addressing coating uniformity and sintering challenges when utilizing Zr with HA for bone implants.
Answers from top 4 papers
More filters
| Papers (4) | Insight |
|---|---|
88 Citations | The challenge is the poor bioactivity of Zr's native oxide film, hindering chemical or biological bonding with tissues, necessitating enhancement for improved implant performance. |
8 Citations | The potential challenge for using Zr with HA as a bone implant is the decreased sintering ability, as highlighted in the study on Ti-Nb-Zr-HA biomaterial fabrication. |
| The study found that Zr with HA coating did not significantly enhance bone integration compared to Ti implants. Therefore, the challenge lies in the limited improvement of bone contact. | |
6 Citations | The potential challenge for using Zr with HA as a bone implant could be the understanding of Zr4+ adsorption on HA nanocrystals at different pH levels, as discussed in the study. |
Related Questions
How does molecular tissue and osseointegration respond between zirconia implant and titanium implant?5 answersMolecular tissue response and osseointegration between zirconia and titanium implants have been extensively studied. Zirconia implants with modified surfaces have shown promising osseointegration features similar to titanium implants, as indicated by histological and micro-CT evaluations. Additionally, zirconia implants with a TiO2 coating subjected to UV light have demonstrated enhanced biological inertness, promoting cell proliferation, ALP activity, mineralization, and upregulation of osteogenesis-related genes, ultimately maximizing osseointegration. On the other hand, TiZr implants have shown comparable biomechanical outcomes to pure titanium implants up to 12 weeks, with significant upregulation of osteogenesis and osteoclastogenesis markers in the early healing stages, indicating a robust genetic response promoting bone formation around TiZr implants.
What is the potential challenge for using Zr as bone implant?5 answersThe potential challenge for using Zirconium (Zr) as a bone implant lies in its bioinert nature, making integration with biomaterials difficult. Zr itself is known for its excellent mechanical properties and biocompatibility. To address this challenge, researchers have explored various approaches such as incorporating Zr with other elements like titanium (Ti), molybdenum (Mo), and zirconium oxide (ZrO2) to enhance its properties and bioactivity for bone repair applications. Strategies like plasma electrolytic oxidation have been employed to create rough and porous ZrO2 coatings containing calcium phosphate on pure Zr, aiming to improve its bioactivity and potential as an orthopedic implant material. These innovative methods aim to overcome the inherent bioinertness of Zr and enhance its suitability for bone implant applications.
What are the challenges in treating fractures?4 answersThe challenges in treating fractures include the risk of significant complications, timing of initial operative debridement, management of critical-sized bone defects, and soft tissue management. Distal radius/forearm fractures in adolescent patients are particularly challenging, and the choice of surgical technique and fixation method can influence outcomes. Infections are a common complication of open fractures, and there is a need for evidence-based recommendations for antibiotic administration, surgical timing, bone defect management, and soft-tissue coverage. Deep infections, delayed healing, and nonunion are problematic complications associated with open fractures, and there is a lack of evidence on how to best treat and prevent infection, predict bone healing/nonunion, and augment bone healing. Fracture management in austere environments presents additional challenges due to limited resources, personnel, and local healthcare systems, as well as the need to ensure the safety of medical providers.
What are the applications of zirconium in medical engineering?3 answersZirconium has various applications in medical engineering. It is used in orthopaedic implants and bone tissue regeneration due to its superior biocompatibility and mechanical properties. Zirconium alloys, such as Zr-2.5Nb, are used in total knee and hip replacements for their excellent wear resistance. Zirconium alloys also show low magnetic susceptibility, making them suitable for suppressing artifacts in magnetic resonance imaging (MRI). Additionally, zirconium alloys form an intrinsic bone-like apatite layer on their surfaces in body environments, enhancing their biocompatibility and corrosion resistance. Zirconium-based bulk metallic glasses (BMGs) are also being assessed for their potential as implant materials. Overall, zirconium and its alloys offer promising applications in medical engineering, particularly in orthopaedic and dental implants, due to their unique properties and excellent biocompatibility.
What are the challenges in developing biopolymer-based implant coatings?5 answersDeveloping biopolymer-based implant coatings faces several challenges. One major challenge is weak osseointegration and post-operational infections, which restrict the long-term use of implants and may cause tissue damage and implant replacement. Another challenge is the need to enhance the durability and longevity of implants by minimizing obstructions such as adhesion, inflammation, and bacterial attack. Additionally, maintaining the nutritive value, keeping quality, and increasing the shelf life of food materials coated with biopolymer compounds is a challenge for the food industry. Furthermore, the severe damage caused by petro-chemical-based polymers highlights the need for biobased polymers derived from sustainable and renewable natural sources. Lastly, the development of renewable and sustainable materials to replace conventional materials is a challenge in the current era, but biopolymer-based composites show promise in achieving similar or better performance.
What are the challenges when removing zirconia dental?0 answersRemoving zirconia dental restorations presents several challenges. Dentists struggle with restoration removal or replacement and shade matching and translucency. Additionally, debonding is a common issue, with more than 50% of respondents experiencing debonding more often with zirconia restorations compared to metal ceramic restorations. The cutting effectiveness of diamond burs on monolithic sintered zirconia also affects the removal process. Different types of diamond burs have varying cutting effectiveness, with super coarse and coarse diamond burs generally producing better results. Furthermore, zirconia crowns can have cracks between the zirconia and layered ceramic, leading to failures. These challenges highlight the need for dentists to have tips on the best methods to remove, shade match, and adhesively bond zirconia restorations. Further research is necessary to investigate the surface contamination and composition of zirconia crowns made in dental laboratories, as this could affect the bonding of zirconia and layered ceramic.