What is the relationship between aldehyde dehydrogenase deficiency and anxiety in patients?
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Aldehyde dehydrogenase (ALDH2) deficiency, which leads to the accumulation of acetaldehyde, has been associated with anxiety and depression in patients with alcohol dependence . ALDH2 deficiency is commonly found in East Asian populations and is known to cause the "Asian flush syndrome" characterized by alcohol-induced facial flushing, tachycardia, nausea, and headaches . The association between ALDH2 deficiency and anxiety in patients with alcohol dependence is influenced by the interaction between ALDH2 and dopamine D2 receptor (DRD2) genes . Specifically, the association between the DRD2 gene and anxiety-depression alcohol dependence (ANX/DEP ALC) is shown to be under the control of ALDH2 and ADH1B genotypes . Therefore, ALDH2 deficiency may contribute to the development of anxiety in patients with alcohol dependence, particularly in the context of specific genetic interactions .
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