What is the relationship between Aspartate Aminotransferase (AST) levels and kidney in chronic kidney disease?
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In chronic kidney disease (CKD), there is a notable relationship between Aspartate Aminotransferase (AST) levels and kidney function. Studies have shown that in CKD patients, especially those undergoing hemodialysis, AST levels tend to be lower compared to individuals with normal kidney function . This decrease in AST levels in CKD patients who have not undergone dialysis therapy suggests an impact of renal impairment on liver enzymes . Furthermore, elevated AST levels have been associated with diabetic nephropathy (DN) and macroalbuminuria, indicating AST/ALT ratio as an independent risk factor for DN . Overall, the data suggests that AST levels can be influenced by kidney function, with implications for diagnosing and managing liver diseases in CKD patients.
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| Papers (5) | Insight |
|---|---|
| High Aspartate Aminotransferase (AST) levels are associated with an increased risk of diabetic nephropathy (DN) in patients with type 2 diabetes, indicating a potential link between AST and kidney damage. | |
2 Citations | In predialysis chronic kidney disease, AST levels were significantly low, indicating a potential impact of renal impairment on liver enzymes. Further research is needed to understand this relationship. |
30 Jan 2021 29 Citations | Low AST levels may indicate increased cardiovascular risk in chronic kidney disease, reflecting advanced kidney disease. Elevated AST levels are associated with cardiovascular risk factors in this population. |
| Elevated Aspartate Aminotransferase (AST) levels were not independently associated with chronic kidney disease measures in Hispanic/Latino adults, as per the Hispanic Community Health Study/Study of Latinos. | |
| In chronic kidney disease, serum AST levels were lower in patients with impaired kidney function, showing a positive correlation with eGFR and a negative correlation with serum creatinine levels. |
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