What is the relationship between the genotypes and body weight?
Best insight from top research papers
Body weight is influenced by genetic factors, with different genotypes having distinct effects on body weight. Genetic loci have been identified that specifically affect adiposity or muscle growth, indicating that these traits are influenced by different genetic factors . Significant differences in body weight and body measurements have been found between different genotypes of horses, such as Thoroughbred, Gidran, Nonius, Hungarian Sport Horse, Hungarian Cold Blooded Horse, and Murinsulaner type . Genetic variation plays a major role in determining inter-individual differences in susceptibility to environmental factors that influence energy intake and expenditure, which in turn affects body weight . Polymorphisms in the perilipin gene have been associated with body-weight regulation, with certain genotypes being related to lower body weight and body fat . Body weight regulation is a complex trait influenced by a combination of genetic and environmental factors, with over a hundred genetic variants involved in metabolic pathways related to obesity .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| The paper discusses the relationship between genetic factors and body weight regulation. It mentions that body weight is determined by a combination of genetic and environmental factors, and that there are genetic variants associated with obesity risk and adiposity measurements. However, it does not specifically mention the relationship between genotypes and body weight. | |
38 Citations | The paper found that certain genotypes in the PLIN gene were associated with lower body weight and body fat in both men and women. |
| The paper discusses how genetic variation plays a major role in determining inter-individual differences in susceptibility or resistance to environmental factors that influence body weight. | |
| The paper states that there are significant differences in body weight among the different genotypes of adult brood mares. The Hungarian Cold Blooded Horse had the highest average weight, while the Thoroughbred had the lowest. | |
27 Citations | The paper discusses the relationship between genetic loci and different phenotypes influencing body weight, specifically distinguishing between loci that affect adiposity and those that affect muscle growth. |
Related Questions
How is polymorphism and genotype and phenotype linked?5 answersPolymorphism is linked to genotype and phenotype through their influence on personalized medicine and disease understanding. Genetic polymorphisms, variations in genes, can affect the efficacy of drugs and make individuals susceptible to certain diseases, including cancer. Understanding and detecting genetic polymorphisms early on in patients can help in selecting the correct medication and dosage for personalized treatment plans. Genotype refers to the genetic makeup of an individual, while phenotype is the observable characteristics of an organism. The study of genotype-phenotype associations is crucial for explaining the pathogenesis of complex diseases and developing genomic medicine. Advances in sequencing technologies and epigenetic studies have provided insights into the genetic basis and epigenetic control of diseases, bridging the gap between genotype and phenotype. Joint analysis of multiple phenotypes and genotypes can identify pleiotropic loci and explore the relationships between phenotypes and genotypes at a higher level of organization.
How are calories linked to body weight?5 answersCalories are linked to body weight in various ways. The amount of energy transferred from the stomach to the intestine after consuming a meal is influenced by body weight, with heavier individuals transferring more energy to the intestine. It is important to match caloric intake with energy expenditure to maintain a healthy body weight. However, the assumption that all calories have the same effect on body weight is questionable, as different calorie sources can have different effects on physiological pathways and hormones relevant to weight maintenance and body fat composition. Studies have shown that caloric restriction can reduce tumor incidence, while high caloric intake and relative body weight have been associated with an increased risk of various cancers. Increases in the amount of energy in food have been linked to rising obesity rates in many countries.
How do genes impact weight?5 answersGenes impact weight through an interplay between genetic susceptibility and changes in dietary habits and lifestyles. Genetic variations determine body weight and obesity risk by controlling food intake and energy balance. Dietary factors such as sugar-sweetened beverages and fried foods can modify genetic associations with body weight and obesity risk. Individual variability in weight loss and maintenance in response to diet interventions is influenced by genotypes. Rare genetic obesity disorders caused by gene mutations contribute to severe obesity and insatiable hunger. Genes play a role in the processes leading to obesity, including eating behavior, metabolism, energy intake, and adiposity. The genetic component can contribute to 40-70% of obesity. The increase in obesity prevalence is influenced by genetic, environmental, and behavioral factors. A genetic diagnosis can inform management and clinical decision-making regarding obesity treatment.
What genes are associated with obesity?5 answersSeveral genes have been associated with obesity, including FTO, LEP, LEPR, PPARG, MC4R, INSIG2, PCSK1, ADRB2, UCP2, ADIPOQ, CEPT, and FABP2. These genes have been found to contribute to childhood obesity, adolescent obesity, and young adult obesity. Genetic variations in these genes have been shown to increase the risk of obesity and have a significant impact on body weight. Additionally, rare genetic variants in the leptin-melanocortin signaling pathway genes, including LEPR, PCSK1, POMC, MC3R, and MC4R, have been identified as potential markers for severe childhood obesity. Furthermore, DNA methylation analysis has revealed several differentially methylated genes, such as CCRL2, GPT, LGALS12, PC, SLC27A2, SLC4A4, and TTC36, that are associated with obesity. These findings highlight the complex genetic factors involved in obesity and provide insights into potential therapeutic targets for managing obesity.
How genetic influence Height?5 answersGenetic factors play a significant role in determining human height. Studies of twins have shown that up to 80% of height variation is due to genetic factors. Genome-wide studies have identified specific DNA markers and genes associated with height. For example, a study on individuals of European ancestry identified nearly 10,000 DNA markers that explain the influence of common genetic variants on height. Another study found a significant correlation between a variant of the GHSR gene and height in men. Additionally, a study on twin cohorts from different regions found that the relative genetic contribution to height increases with age, with the greatest contribution observed in adolescence. Overall, while genetic factors explain a major proportion of height variation, it is likely that multiple genes with small individual effects contribute to the genetic architecture of height.
How do genetics affect obesity?5 answersGenetics play a significant role in obesity. Monogenic obesity, a rare and severe form of obesity, is caused by defects in the leptin-melanocortin pathway. Common polygenic obesity, on the other hand, is influenced by multiple genetic variants with low penetrance. Genetic studies have identified many obesity-associated loci, most of which are involved in the leptin-melanocortin pathway. Genetic obesities, including monogenic and syndromic obesities, have a predominant genetic contribution. Several genes, such as FTO, LEP, LEPR, PPARG, MC4R, INSIG2, PCSK1, ADRB2, and UCP2, have been associated with obesity. The Human Genome project and Genome-Wide Association Studies (GWAS) have contributed to the understanding of genetic factors in obesity. Epigenetics, the study of heritable changes in gene expression, has also shed light on the interaction between genetics and the environment in obesity. Overall, genetics play a crucial role in the development and understanding of obesity.