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What is the role of HMG-CoA reductase in cholesterol biosynthesis and cancer development?

Hippo signaling pathway

Germ line development

Mevalonate pathway

Germ cell migration

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HMG-CoA reductase plays a crucial role in cholesterol biosynthesis by catalyzing a rate-limiting step in the pathway . Statins, which are inhibitors of HMG-CoA reductase, effectively lower serum cholesterol levels and are widely used in the treatment of hypercholesterolemia . In addition to its role in cholesterol synthesis, HMG-CoA reductase has been found to have a cholesterol-independent role in regulating a developmental process called primordial germ cell migration . The mevalonate pathway, regulated by HMG-CoA reductase, is responsible for cholesterol enrichment in cells and is critically involved in cell proliferation . Increased rates of cholesterol and lipid synthesis are important aspects of cancerous transformation, and HMG-CoA reductase is a transcriptional target of the sterol regulatory element-binding proteins (SREBPs) that play a role in cancer development . The complex regulation surrounding the Hippo-p53-SREBP network provides potential targets for cancer interventions .

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Open access•Journal Article•DOI The Hippo pathway, p53 and cholesterol Yael Aylon, Moshe Oren - Show less +1 more 15 Jul 2016-Cell Cycle 22 Citations	The role of HMG-CoA reductase in cholesterol biosynthesis and cancer development is not mentioned in the provided information.
Journal Article•DOI Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis Rajesh P. Singh, Raj Kumar, Nidhi Kapur - Show less +2 more 01 Jan 2003-Journal of Environmental Pathology Toxicology and Oncology 30 Citations	HMG-CoA reductase is a critical enzyme in cholesterol biosynthesis and its deregulation is associated with cancer development.
Open access•Journal Article•DOI Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR) Laura J. Sharpe, Laura J. Sharpe, Andrew J. Brown - Show less +2 more 28 Jun 2013-Journal of Biological Chemistry 293 Citations	The role of HMG-CoA reductase in cancer development is not mentioned in the provided text.
Journal Article•DOI HMG-CoA reductase guides migrating primordial germ cells Mark Van Doren, Heather T. Broihier, Lisa A. Moore, Ruth Lehmann - Show less +3 more 03 Dec 1998-Nature 187 Citations	HMG-CoA reductase is involved in cholesterol biosynthesis but its role in cancer development is not mentioned in the provided information.
Journal Article•DOI Structural mechanism for statin inhibition of HMG-CoA reductase. Eva S. Istvan, Johann Deisenhofer - Show less +1 more 11 May 2001-Science 1.3K Citations	The role of HMG-CoA reductase in cancer development is not mentioned in the provided text.

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Do oyster mushrooms inhibit HMG-CoA reductase?5 answersOyster mushrooms, specifically Pleurotus ostreatus, have been found to inhibit HMG-CoA reductase, an enzyme involved in cholesterol synthesis. Water extracts from Pleurotus ostreatus containing specific water-soluble polysaccharides (WSPs) showed inhibitory activity against HMG-CoA reductase in vitro. Addition of dried oyster mushroom to the diet of rats resulted in a significant reduction in cholesterol content in serum, lipoproteins, and liver, as well as a decrease in the activity of HMG-CoA reductase in liver microsomes. Furthermore, a water-soluble polysaccharide from Oudemansiella radicata, another type of mushroom, was found to have antifungal activity against Penicillium digitatum, which was attributed to disruption of hyphal cell membrane integrity and impaired cellular metabolism. Overall, these findings suggest that oyster mushrooms, including Pleurotus ostreatus, have the potential to inhibit HMG-CoA reductase and may have beneficial effects on cholesterol levels.

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