What is the role of sestrin 1 and 2 in fishes' development and survival?
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Sestrins, including Sestrin 1 and 2, play crucial roles in promoting cell survival and adaptation to stress conditions in various animal species, including fishes. Sestrin 1, 2, and 3 are activated in response to stimuli like oxidative stress and regulate metabolic shifts to enhance cell survival . Sestrin 2, specifically, acts as an antioxidant and regulator of metabolism, inhibiting oxidative stress and inflammation while promoting autophagy and apoptosis in cancer cells . In hypoxic conditions, Sestrin 2 reduces reactive oxygen species production through pathways like AMPK/mTOR and Nrf2, contributing to cytoprotection . These functions of Sestrin 1 and 2 are vital for fishes' development and survival by aiding in stress adaptation, antioxidant responses, and metabolic regulation.
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17 Citations | Sestrin 1 and 2 proteins in fishes play a crucial role in promoting cell survival under stress by activating antioxidant response and autophagy, aiding in development and survival. |
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