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What is the role of TRPA1 in chemical sensing in humans?

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TRPA1 is a polymodal receptor involved in chemical sensing in humans. It is expressed in nociceptive nerve endings and plays a prominent role in pain signaling . TRPA1 is activated by diverse chemical irritants and is involved in detecting oxidative and nitrosative stress . However, the other sensory features of TRPA1 in humans are still not fully understood . TRPA1 is a Ca2+-permeable cation channel that recognizes electrophiles through covalent bond modifications of specific cysteine residues . The channel is activated by electrophilic molecules, which cause the sensation of pain . TRPA1 has been implicated in severe pain disorders, and genetic variants of TRPA1 have been associated with neuronal hyperexcitability-hypersensitivity symptoms . The role of TRPA1 in chemical sensing in humans is still an area of ongoing research, and further studies are needed to fully elucidate its functions .

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Open access•Posted Content•DOI Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights Avnika P. Bali, Samantha P. Schaefer, Isabelle Trier, Alice L. Zhang, Lilian Kabeche, Candice E. Paulsen - Show less +5 more 05 Jan 2022-bioRxiv	The paper does not provide information about the role of TRPA1 in chemical sensing in humans.
Journal Article•DOI Mini-review: The nociceptive sensory functions of the polymodal receptor Transient Receptor Potential Ankyrin Type 1 (TRPA1). Alexandra Manolache, Alexandru Babes, Ramona Madalina Babes - Show less +2 more 05 Oct 2021-Neuroscience Letters 12 Citations	The paper states that the chemosensory function of TRPA1 is well demonstrated, indicating that TRPA1 plays a role in chemical sensing in humans.
Journal Article•DOI The role of TRPA1 channels in thermosensation Hao Zhang, Chengsan Wang, Keyi Zhang, Peter Muiruri Kamau, Anna Luo, Lifeng Tian, Ren Lai - Show less +6 more 01 Oct 2022-Cell insight 2 Citations	The paper does not provide information about the role of TRPA1 in chemical sensing in humans.

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