What is the solubility profile of amphotericin b?
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The solubility profile of amphotericin B (AmB) has been studied in various solvents. The solubility was found to be remarkably low in all solvents, with the highest solubility observed in ethanol, followed by tetrahydrofuran, butanol, 1,4-dioxane, isopropanol, and acetone . Cyclodextrins, specifically gamma cyclodextrin, were found to enhance the solubility of AmB in semisolid topical formulations, resulting in improved permeability and antifungal activity . Nanoemulsion formulations containing AmB were also developed to increase its solubility and bioavailability, with the nanoemulsion formulation NE2 showing a significantly higher drug release profile compared to the suspension of AmB . Water-lecithin-dispersions (WLDs) and lecithin-based submicron emulsions (SMEs) were found to solubilize AmB, with higher lecithin content leading to increased solubilization in both WLDs and SMEs .
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| The paper mentions that the solubility study was conducted to optimize the oil phase, but it does not provide specific information about the solubility profile of amphotericin B. | |
| The solubility profile of amphotericin B is not mentioned in the provided paper. The paper focuses on the permeability characteristics of a new antifungal topical formulation of amphotericin B with γ-cyclodextrins. | |
3 Citations | The solubility profile of amphotericin B in pure organic solvents was studied, and it was found to be remarkably low, with the highest solubility observed in ethanol. |
| The solubility profile of amphotericin B is not mentioned in the provided paper. The paper focuses on the pharmacokinetic profile of amphotericin B in different rat strains following intravenous administration. |
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