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What is tumor to tumor metastasis?

Epithelial–mesenchymal transition

Renal cell carcinoma

Pancreatic tumor

Breast carcinoma

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Tumor-to-tumor metastasis is a rare phenomenon where primary tumor cells spread hematogenously to another tumor. This unique occurrence involves one distinct malignancy within the substance of another independent tumor, making it challenging to detect and classify due to conflicting terminology in the literature. Examples include renal cell carcinoma metastasizing into a pancreatic neuroendocrine tumor, lung cancer metastasizing to a thymoma, and prostatic adenocarcinoma metastasizing to myxoid liposarcoma. Understanding tumor-to-tumor metastasis is crucial for accurate diagnosis and treatment decisions, as it can impact the progression of both primary and secondary tumors. This rare occurrence underscores the complexity of cancer metastasis and the need for careful consideration in managing such cases.

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Open access•Journal Article•DOI Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient Shunryo Minezaki, Takeyuki Misawa, Hiroyuki Tsukayama, Makoto Shibuya, Keita Wada, Keiji Sano, Makoto Mochizuki, Yuko Sasajima, Hitoshi Kondo - Show less +8 more 10 Jan 2022-Surgical case reports 3 Citations	Tumor-to-tumor metastasis is a rare occurrence where primary tumor cells spread to another tumor. In this case, renal cell carcinoma metastasized into a pancreatic neuroendocrine tumor, a highly unusual event.
Journal Article•DOI The overall process of metastasis: From initiation to a new tumor. Tianyue Fan, Guicheng Kuang, Runmin Long, Junwei Han, Jing Wang - Show less +4 more 01 Jun 2022-Biochimica Et Biophysica Acta - Reviews On Cancer 7 Citations	Tumor to tumor metastasis refers to the spread of cancer cells from one tumor to another distinct tumor site, contributing to cancer progression and increased metastatic potential.
Open access•Journal Article•DOI Tumor-to-tumor metastasis: a rare case of breast carcinoma metastasizing to a pheochromocytoma, and a literature review. Weiwei Tan, Li-Li Tao, Zhuping Zhou, Weihua Yin, Yaoli Chen - Show less +4 more 20 May 2019-Diagnostic Pathology 4 Citations	Tumor-to-tumor metastasis is a rare occurrence where cancer from one primary tumor spreads to another distinct tumor, as seen in breast carcinoma metastasizing to a pheochromocytoma.
Journal Article•DOI Tumor-to-Tumor Metastasis: Prostate Carcinoma Metastatic to Soft Tissue Sarcoma, a Previously Unreported Event. Virginia Miller, Jason S. Hoellwarth, Margaret L. Hankins, Richard L. McGough, Karen E. Schoedel - Show less +4 more 01 Apr 2020-International Journal of Surgical Pathology 4 Citations	Tumor-to-tumor metastasis is a rare occurrence where one cancer spreads to another distinct tumor. The paper presents a unique case of prostate carcinoma metastasizing to soft tissue sarcoma.

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