What makes CTV infectious clone vectors different from conventional CTV vectors, based on structure?
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CTV infectious clone vectors differ from conventional CTV vectors structurally due to their ability to house full-length cDNA genomes and express exogenous genes like GFP. These infectious clones are obtained through in-vitro methods and electrotransfection, allowing for efficient mutagenesis and reproducible production of genetically-defined strains. In contrast, conventional CTV vectors lack the capacity to express exogenous genes and do not provide the same level of genetic manipulation and control as infectious clones. Additionally, the infectious clone vectors can be used for research on coronavirus pathogeny biology, vaccine development, and expressing other exogenous proteins, showcasing their versatility and utility in virology research.
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| Papers (5) | Insight |
|---|---|
| CTV infectious clone vectors differ by incorporating self-excising design with loxP sites and CREin gene, enabling efficient removal of vector backbone post-delivery into mammalian cells, unlike conventional CTV vectors. | |
5 Citations | CTV infectious clone vectors differ from conventional CTV vectors in structure due to the presence of markers for the p23 gene, multiple molecular markers, and sequence analysis of silencing suppressor genes. |
| The infectious clone vectors of HCoV-NL63 Chinese strain contain a full-length cDNA and a related RNA virus vector, enabling expression of exogenous genes like GFP, aiding in virus research and vaccine development. | |
2 Citations | CTV infectious clone vectors differ structurally from conventional CTV vectors by containing recombinant elements, enabling precise genetic manipulation for research purposes. |
| The infectious clone vectors of HCoV-NL63 Chinese strain contain full-length cDNA and can express exogenous genes like GFP, enabling virus rescue and research applications, unlike conventional vectors. |
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