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What's the SIOP2001 clinical trial about? 

Stakeholder
Liver disease
Sarcoma
Metastasectomy
Population
Best insight from top research papers

The SIOP2001 clinical trial focused on Wilms tumor, a rare childhood kidney cancer. It aimed to assess the impact of liver metastases on the outcome of patients with Wilms tumor, showing that liver involvement did not appear to be an adverse prognostic factor in metastatic Wilms tumor. The trial also explored the role of hepatic surgery and radiotherapy in cases of persistent liver metastases, emphasizing the importance of considering histology and radiological response to other metastatic sites. Additionally, the trial incorporated genetic analysis, specifically investigating the prognostic significance of chromosome arm 1q gain in Wilms tumors, highlighting its association with inferior event-free survival and overall survival rates. The SIOP2001 trial contributed valuable insights into the treatment and prognosis of Wilms tumor, enhancing understanding and management strategies for this pediatric malignancy.

Answers from top 5 papers

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Papers (5)Insight
Journal Article•DOI
Results of the SIOP 93-01/GPOH Trial and Study for the Treatment of Patients with Unilateral Nonmetastatic Wilms Tumor
Harald Reinhard, Oliver Semler, D. Bürger, Udo Bode, Michael Flentje, Ulrich Göbel, P. Gutjahr, Ivo Leuschner, Eberhard Maass, Felix Niggli, Hans-Gerhard Scheel-Walter, Michael Stöckle, Thüroff Jw, Jochen Tröger, A. Weirich, von Schweinitz D, Andreas Zoubek, Norbert Graf 
01 May 2004-Klinische Padiatrie
109 Citations
The SIOP 93-01/GPOH trial focused on preoperative therapy for unilateral nonmetastatic Wilms tumor, evaluating reducing postoperative chemotherapy without compromising efficacy based on tumor volume and histology.
Open access•Journal Article•DOI
Op0303-pare multi-stakeholder co-creation to facilitate clinical trial recruitment - a feasibility study
M. G. P. S. De Silva, N. Caeyers 
30 May 2023-Annals of the Rheumatic Diseases
Not addressed in the paper.
Journal Article•DOI
Liver metastasis at diagnosis in children with nephroblastoma enrolled in SIOP2001 protocol: A French multicentric study.
Antoine Liné, Hélène Sudour-Bonnange, Virginie Languillat-Fouquet, Hervé Brisse, Sabine Irtan, Arnauld Verschuur, Sabine Sarnacki, Estelle Thebaud, Aurore Coulomb-L'Hermine, Anne Notz-Carrere, Jean Michon, Marie-Dominique Tabone, Cécile Boulanger, Isabelle Pellier, Claire Freycon, Georges Audry, Frédérique Dijoud, Magali Morelle, Christophe Bergeron, Claudia Pasqualini 
01 Jun 2020-Pediatric Blood & Cancer
5 Citations
The SIOP2001 trial studied liver metastasis impact on children with Wilms tumor. Liver involvement didn't affect prognosis; hepatic surgery and radiotherapy roles need clarification for persistent metastases.
Open access•Journal Article•DOI
The Clinical Trials Mosaic: Toward a Range of Clinical Trials Designs to Optimize Evidence-Based Treatment.
Ty A. Ridenour, Szu-Han Kay Chen, Hsin-Yi Liu, Georgiy Bobashev, Katherine A. Hill, Rory A. Cooper, Rory A. Cooper 
01 Nov 2017
5 Citations
Not addressed in the paper.
Journal Article•DOI
1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk stratification in the SIOP2001/GPOH trial.
Christian Vokuhl, Wiebke Vogelgesang, Ivo Leuschner, Rhoikos Furtwängler, Norbert Graf, Manfred Gessler, Evelyn Dörner, Torsten Pietsch 
01 Nov 2014-Genes, Chromosomes and Cancer
3 Citations
The SIOP2001 clinical trial focuses on risk stratification in Wilms tumors based on stage and histopathologic classification after preoperative chemotherapy, with limited prognostic value for 1q gain.

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