What year was considered to be the first randomized clinical trial?
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13 Citations | This experiment is generally considered to be the first clinical trial in the United States that used a formal system of randomization to divide research subjects into treatment and nontreatment groups; it was probably also the first clinical trial in the United States to use placebo shams in a nontreatment control group to overcome the problem of what researchers at the time called “psychic influence.” As such, it was an extremely important moment in the history of clinical trial design. |
71 Citations | This randomized trial is the first report of such a national study completed to date. |
48 Citations | The first randomized clinical trial provides compelling support for a new trial designed to fully test the original hypothesis. |
Open access•Journal Article 3 Citations | This was the first ever clinical trial in this population. |
| We concluded that one third of clinical trials supporting drug approvals for rare cancer indications were randomized, affirming the feasibility and value of randomized trial design to evaluate drugs for rare cancers. | |
Open access•Journal Article 20 Citations | One randomized clinical trial can have an immediate and profound effect on medical practice. |
45 Citations | To our knowledge we present the first randomized trial to study its safety and efficacy. |
8 Citations | Randomized phase II clinical trials can be an efficient means of evaluating several potential new treatments prior to a comparative phase III clinical trial. |
| The randomized controlled trial is the strongest study design. | |
| This approach should be considered early in the design of randomized clinical trials. |
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